Gsr - glutathione reductase Gene

Also Known as Gr1; Gr-1; D8Ertd238e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14782

Summary

Enables glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in several processes, including cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Located in external side of plasma membrane. Is expressed in brain ventricular layer; gut; lung; metanephros; and retina. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Apr 2022]

Gsr Products (1)

mRNA Protein Name
NM_010344.4 NP_034474.4 glutathione reductase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione-disulfide reductase (NADPH) activity IDA
IDA: Inferred from direct assay
204065 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
24029230 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione reductase, mitochondrial

  • GR

  • GRase

  • glutathione reductase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147328 LCS3 Inducer 99.43% Unkown
HY-N7653 Azaleatin 98.86% Unkown
HY-RS05870 GSR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18327 Gsr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24806 Gsr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsr NCBI NCBI:2936