Hgs - HGF-regulated tyrosine kinase substrate Gene

Also Known as tn; Hgr; Hrs; ZFYVE8

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15239

Summary

Enables identical protein binding activity and ubiquitin-dependent protein binding activity. Predicted to be involved in several processes, including lysosomal transport; negative regulation of signal transduction; and positive regulation of exosomal secretion. Predicted to act upstream of or within protein transport. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; olfactory epithelium; retina layer; and spleen. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). [provided by Alliance of Genome Resources, Apr 2022]

Hgs Products (2)

mRNA	Protein	Name
NM_001159328.1	NP_001152800.1	hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1
NM_008244.3	NP_032270.3	hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16615908	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12802020	MGI
enables ubiquitin-modified protein reader activity	IDA IDA: Inferred from direct assay	11916981	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7565774	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hepatocyte growth factor-regulated tyrosine kinase substrate

Hgs Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Hgs	Q99LI8	STAM	Homo sapiens	Q92783-1	DLS	19278655
Intra	Hgs	Q99LI8	STAM	Homo sapiens	Q92783-1	Solution Sedimentation	19278655
Intra	Hgs	Q99LI8	STAM	Homo sapiens	Q92783-1	Light Scattering	19278655
Intra	Hgs	Q99LI8	STAM	Homo sapiens	Q92783-1	GMS	19278655
Cross	Hgs	Q99LI8	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	12802020
Cross	Hgs	Q99LI8	TSG101	Homo sapiens	Q99816	IF	12900395
Intra	Hgs	Q99LI8	Ntrk2	Mus musculus	P15209	Anti Bait CoIP	20956301
Intra	Hgs	Q99LI8	Hap1	Mus musculus	O35668	Anti Bait CoIP	20956301
Intra	Hgs	Q99LI8	Hgs	Mus musculus	Q99LI8	GMS	16615908
Cross	Hgs	Q99LI8	TSG101	Homo sapiens	Q99816	Pull Down	12900395
Cross	Hgs	Q99LI8	TSG101	Homo sapiens	Q99816	Y2H	12900395
Intra	Hgs	Q99LI8	Hgs	Mus musculus	Q99LI8	3D-EM	16615908
Cross	Hgs	Q99LI8	TSG101	Homo sapiens	Q99816	IF	12802020

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-120434	AEG40826	Inhibitor	/	Phase 1

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99299	Lexatumumab	Inducer	99.87%	Phase 2
HY-P990592	GSK-3050002		97.30%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06155	HGS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991541	HGS101		/	Unkown
HY-P991653	HGS004	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hgs	NCBI	NCBI:9146