Hap1 - huntingtin-associated protein 1 Gene

Also Known as HAP-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15114

Summary

The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein Huntingtin. The protein also interacts with Kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Hap1 Products (3)

mRNA	Protein	Name
NM_001359052.1	NP_001345981.1	huntingtin-associated protein 1 isoform C
NM_010404.3	NP_034534.1	huntingtin-associated protein 1 isoform A
NM_177981.2	NP_817090.1	huntingtin-associated protein 1 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9599014	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	24355921	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	18636121	MGI
involved in hypothalamus cell differentiation	IMP IMP: Inferred from mutant phenotype	24355921	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	18636121	MGI
involved in neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24355921	MGI
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IMP IMP: Inferred from mutant phenotype	15379999	MGI
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	24355921	MGI
acts upstream of or within positive regulation of non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21985783	MGI
involved in positive regulation of non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21985783	MGI
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	24366265	MGI
involved in regulation of organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	24453320	MGI
acts upstream of or within vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	15242649	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in autophagosome	IDA IDA: Inferred from direct assay	24453320	MGI
located in centriole	IDA IDA: Inferred from direct assay	21985783	MGI
located in centrosome	IDA IDA: Inferred from direct assay	21985783	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15242649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
huntingtin-associated protein 1

Hap1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Hap1	O35668	Ahi1	Mus musculus	Q8K3E5	Anti Bait CoIP	21146532

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170316	Ibetazol	Inhibitor	99.80%	Unkown
HY-150221	DB008	Inhibitor	98.47%	Unkown
HY-153119	TMX-4153	Degrader	98.96%	Unkown
HY-180573	ART5537	Inhibitor	99.84%	Unkown
HY-174866	BT-O2C	Inhibitor	99.31%	Unkown
HY-RS00815	APEX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P4096	HAP-1		99.08%	Unkown
HY-173281	MAT2A-IN-24	Inhibitor	/	Unkown
HY-174296	TMX-4102		/	Unkown
HY-RS06000	HAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17886	Hap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21480	Apex1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24355	Hap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hap1	NCBI	NCBI:9001