Hipk3 - homeodomain interacting protein kinase 3 Gene

Also Known as PKY; DYRK6; FIST3; mir-1902

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15259

Summary

Enables protein serine/threonine kinase activity. Involved in negative regulation of JUN kinase activity; peptidyl-serine phosphorylation; and peptidyl-threonine phosphorylation. Located in PML body and cytoplasm. Is expressed in diaphragm; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hipk3 Products (2)

mRNA Protein Name
NM_001145824.1 NP_001139296.1 homeodomain-interacting protein kinase 3 isoform 2
NM_010434.2 NP_034564.2 homeodomain-interacting protein kinase 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11034606 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11034606 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
11034606 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
11034606 MGI
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
11034606 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in PML body IDA
IDA: Inferred from direct assay
11034606 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11034606 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeodomain-interacting protein kinase 3

  • ANPK

  • FIST

  • HCMV-interacting protein

  • androgen receptor-interacting nuclear protein kinase

  • fas-interacting serine/threonine-protein kinase

  • nbak3

  • nuclear body-associated kinase 3

Hipk3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Hipk3 Q9ERH7 Fas Mus musculus P25446
Y2H
11034606
Intra
Hipk3 Q9ERH7 Fas Mus musculus P25446
CoIP
11034606
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-123853 CAM4066 Inhibitor / Unkown
HY-177416 MU1787 Inhibitor 99.84% Unkown
HY-RS06183 HIPK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19440 Hipk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25932 Hipk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hipk3 NCBI NCBI:10114