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Hlx - H2.0-like homeobox Gene

Also Known as Hlx1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15284

Summary

Predicted to enable sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Hlx Products (1)

mRNA	Protein	Name
NM_008250.2	NP_032276.1	H2.0-like homeobox protein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of T-helper 1 cell differentiation	IGI IGI: Inferred from genetic interaction	16424184	MGI
acts upstream of T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	16424184	MGI
acts upstream of T-helper 2 cell differentiation	IGI IGI: Inferred from genetic interaction	16424184	MGI
acts upstream of T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	16424184	MGI
acts upstream of or within animal organ development	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within enteric nervous system development	IMP IMP: Inferred from mutant phenotype	16854219	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within negative regulation of T-helper 2 cell differentiation	IGI IGI: Inferred from genetic interaction	16424184	MGI
acts upstream of or within negative regulation of T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	16424184	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within positive regulation of T-helper 1 cell differentiation	IGI IGI: Inferred from genetic interaction	16424184	MGI
acts upstream of or within positive regulation of T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	16424184	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	8557196	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	8557196	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
H2.0-like homeobox protein	H2.0-like homeo box 1 homeobox protein HLX1

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99118	Serplulimab		99.30%	Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991588	HLX-22		99.47%	Phase 3
HY-P991605	HLX26	Inhibitor	/	Phase 2
HY-P99785	Opucolimab	Inhibitor	99.18%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177439	HLX43	Inhibitor	99.60%	Unkown
HY-123773	SR-16157		/	Unkown
HY-RS06221	HLX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99516	Vulinacimab	Inhibitor	99.40%	Unkown
HY-P992368	HLX51	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hlx	NCBI	NCBI:3142