Kcna5 - potassium voltage-gated channel, shaker-related subfamily, member 5 Gene

Also Known as Kv1.5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16493

Summary

Enables Potassium Channel Inhibitor activity and voltage-gated Potassium Channel activity. Acts upstream of or within several processes, including negative regulation of potassium ion transport; potassium ion transport; and regulation of vasoconstriction. Located in intercalated disc and plasma membrane. Is expressed in several structures, including gut; heart; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]

Kcna5 Products (1)

mRNA Protein Name
NM_145983.2 NP_666095.1 potassium voltage-gated channel subfamily A member 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15277200 MGI
NOT enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
8226976 MGI
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
8226976 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
15277200 MGI
acts upstream of or within regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
11481235 MGI
Cellular Component GO Annotation Evidence References Source
located in intercalated disc IDA
IDA: Inferred from direct assay
18603586 MGI
located in membrane IDA
IDA: Inferred from direct assay
18603586 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15277200 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily A member 5

  • KV1-5

  • voltage-gated potassium channel subunit Kv1.5

Kcna5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kcna5 Q61762 Xirp2 Mus musculus Q4U4S6
Anti Bait CoIP
29306897
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07101 KCNA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcna5 NCBI NCBI:3741