Kcna5 - potassium voltage-gated channel, shaker-related subfamily, member 5 Gene

Mus musculus

Also known as Kv1.5

Gene ID: 16493 | Gene type: protein coding

About Kcna5

Summary

Enables Potassium Channel Inhibitor activity and voltage-gated Potassium Channel activity. Acts upstream of or within several processes, including negative regulation of potassium ion transport; potassium ion transport; and regulation of vasoconstriction. Located in intercalated disc and plasma membrane. Is expressed in several structures, including gut; heart; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]

Kcna5 Products(1)

mRNA	Protein	Name
NM_145983.2	NP_666095.1	potassium voltage-gated channel subfamily A member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15277200	MGI
NOT enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	8226976	MGI
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	8226976	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	23117660	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	15277200	MGI
acts upstream of or within regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	11481235	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intercalated disc	IDA IDA: Inferred from direct assay	18603586	MGI
located in membrane	IDA IDA: Inferred from direct assay	18603586	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15277200	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily A member 5

KV1-5

voltage-gated potassium channel subunit Kv1.5

Kcna5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Kcna5	Q61762	Xirp2	Mus musculus	Q4U4S6	Anti Bait CoIP	29306897

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07101	KCNA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna5	NCBI	NCBI:3741

Name
Email *

	Sorry, but the email address you supplied was invalid.