SLC40A1 - solute carrier family 40 member 1 Gene

Also Known as Fpn1; Slc11a3; Slc39a1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170840

About SLC40A1

Primary_assembly 9: 48,033,526-48,051,481 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 211 orthologues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 165.6), Liver (RPKM 27.1) and 4 other tissues.

Summary

Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in cellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]

SLC40A1 Products (1)

mRNA Protein Name
NM_133315.2 NP_579849.2 solute carrier family 40 member 1

SLC40A1 Protein Structure

FPN1

FPN1: pfam06963 (21 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

solute carrier family 40 member 1

  • CAR1

  • cell adhesion regulator

  • ferroportin-1

  • solute carrier family 39 (iron-regulated transporter), member 1

  • solute carrier family 40 (iron-regulated transporter), member 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990618 LY2928057 Inhibitor 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13243 SLC40A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13244 Slc40a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13245 SLC40A1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990510 Anti-SLC40A1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SLC40A1 NCBI NCBI:30061