Nck2 - non-catalytic region of tyrosine kinase adaptor protein 2 Gene

Also Known as Grb4; Nck-2; NCKbeta; 4833426I10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17974

Summary

Enables scaffold protein binding activity. Involved in regulation of cellular macromolecule biosynthetic process and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including actin filament organization; Ephrin Receptor signaling pathway; and lamellipodium assembly. Located in vesicle membrane. Is expressed in several structures, including central nervous system; chordamesoderm; gut endoderm; hemolymphoid system gland; and paraxial mesenchyme. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Nck2 Products (1)

mRNA	Protein	Name
NM_010879.3	NP_035009.3	cytoplasmic protein NCK2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17310244	MGI
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	12091389	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	12637565	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	12637565	MGI
acts upstream of or within ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	17310244	MGI
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	12808099	MGI
involved in negative regulation of PERK-mediated unfolded protein response	IGI IGI: Inferred from genetic interaction	14676213	MGI
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IGI IGI: Inferred from genetic interaction	14676213	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16835242	MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16835242	MGI
involved in positive regulation of translation in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	14676213	MGI
involved in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	16835242	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in vesicle membrane	IDA IDA: Inferred from direct assay	12147689	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytoplasmic protein NCK2	NCK adaptor protein 2 SH2/SH3 adaptor protein NCK-beta growth factor receptor-bound protein 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0710	alpha-Cyperone		99.68%	Unkown
HY-173156	UNC10013	Modulator	99.90%	Unkown
HY-171744	CX-5279	Inhibitor	/	Unkown
HY-RS09081	NCK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nck2	NCBI	NCBI:8440