2. Gene
  3. Nck2 - non-catalytic region of tyrosine kinase adaptor protein 2 Gene

Nck2 - non-catalytic region of tyrosine kinase adaptor protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Grb4; Nck-2; NCKbeta; 4833426I10Rik

Gene ID: 17974 | Gene type: protein coding

About Nck2

Summary

Enables scaffold protein binding activity. Involved in regulation of cellular macromolecule biosynthetic process and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including actin filament organization; Ephrin Receptor signaling pathway; and lamellipodium assembly. Located in vesicle membrane. Is expressed in several structures, including central nervous system; chordamesoderm; gut endoderm; hemolymphoid system gland; and paraxial mesenchyme. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Nck2 Products(1)

mRNA Protein Name
NM_010879.3 NP_035009.3 cytoplasmic protein NCK2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17310244 MGI
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12091389 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
12637565 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
12637565 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
17310244 MGI
acts upstream of or within lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
12808099 MGI
involved in negative regulation of PERK-mediated unfolded protein response IGI
IGI: Inferred from genetic interaction
14676213 MGI
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
IGI: Inferred from genetic interaction
14676213 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16835242 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16835242 MGI
involved in positive regulation of translation in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
14676213 MGI
involved in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
16835242 MGI
Cellular Component GO Annotation Evidence Reference Source
located in vesicle membrane IDA
IDA: Inferred from direct assay
12147689 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic protein NCK2

NCK adaptor protein 2

SH2/SH3 adaptor protein NCK-beta

growth factor receptor-bound protein 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0710 alpha-Cyperone 99.68% Unkown
HY-173156 UNC10013 Modulator 99.90% Unkown
HY-171744 CX-5279 Inhibitor / Unkown
HY-RS09081 NCK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nck2 NCBI NCBI:8440