Prkacb - protein kinase, cAMP dependent, catalytic, beta Gene

Also Known as CbPKA; Pkacb; PKA C-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18749

Summary

Enables ATP binding activity; cAMP-dependent protein kinase activity; and magnesium ion binding activity. Involved in protein phosphorylation. Acts upstream of or within negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; and regulation of protein processing. Located in ciliary base. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkacb Products (7)

mRNA Protein Name
NM_001164198.2 NP_001157670.1 cAMP-dependent protein kinase catalytic subunit beta isoform 2
NM_001164199.2 NP_001157671.1 cAMP-dependent protein kinase catalytic subunit beta isoform 3
NM_001164200.2 NP_001157672.1 cAMP-dependent protein kinase catalytic subunit beta isoform 4
NM_001410458.1 NP_001397387.1 cAMP-dependent protein kinase catalytic subunit beta isoform 5
NM_001410459.1 NP_001397388.1 cAMP-dependent protein kinase catalytic subunit beta isoform 6
NM_001410460.1 NP_001397389.1 cAMP-dependent protein kinase catalytic subunit beta isoform 6
NM_011100.5 NP_035230.1 cAMP-dependent protein kinase catalytic subunit beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9368018 MGI
enables cAMP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
9368018 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
9368018 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
22007132 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
22007132 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9368018 MGI
acts upstream of or within regulation of protein processing IGI
IGI: Inferred from genetic interaction
22007132 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary base IDA
IDA: Inferred from direct assay
22007132 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-dependent protein kinase catalytic subunit beta

  • Cbeta2 PKA

  • cAMP-dependent protein kinase C beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11107 PRKACB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkacb NCBI NCBI:5567