Prop1 - paired like homeodomain factor 1 Gene

Also Known as df; Prop-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19127

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; diencephalon development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Prop1 Products (1)

mRNA Protein Name
NM_008936.2 NP_032962.1 homeobox protein prophet of Pit-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16678101 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16678101 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16678101 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
16678101 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16678101 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16678101 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenohypophysis development IMP
IMP: Inferred from mutant phenotype
18996108 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12183375 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
18996108 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
12183375 MGI
acts upstream of or within gland development IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within hypophysis morphogenesis IMP
IMP: Inferred from mutant phenotype
16678101 MGI
acts upstream of or within hypothalamus cell differentiation IMP
IMP: Inferred from mutant phenotype
9067988 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16556738 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678101 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678101 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
11731482 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678101 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16678101 MGI
acts upstream of or within somatotropin secreting cell differentiation IMP
IMP: Inferred from mutant phenotype
6194978 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16678101 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein prophet of Pit-1

  • Ames dwarf

  • pituitary specific homeodomain factor

  • prophet of Pit-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W039899 1,2,3,4,6-Penta-O-acetyl-D-mannopyranose, 97% 99.79% Unkown
HY-W583812 Cbz-PEG2-prop-1-yne / Unkown
HY-W251756 3-(2-Iodoethoxy)prop-1-yne / Unkown
HY-W583811 Cbz-PEG3-prop-1-yne / Unkown
HY-W784556 5'-DMTr-dU(Allylamine-CO-F3)-3'-CE-phosphoramidite / Unkown
HY-N17408 (E)-2-(2-Hydroxy-4-methylpheny1)-prop-l-en-1-yl acetate / Unkown
HY-RS11200 PROP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W784553 Amino-modifier-C6-dC CEP / Unkown
HY-W784554 5'-DMTr-Amino-modifier-C6-dT-3'-CE-phosphoramidite / Unkown
HY-W784555 5'-DMTr-TFA-ap-dU-3'-CE-Phosphoramidite / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prop1 NCBI NCBI:5626