Prop1 - paired like homeodomain factor 1 Gene

Mus musculus

Also known as df; Prop-1

Gene ID: 19127 | Gene type: protein coding

About Prop1

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; diencephalon development; and regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in Rathke's pouch; adenohypophysis; adenohypophysis pars anterior; and pituitary gland. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Prop1 Products(1)

mRNA	Protein	Name
NM_008936.2	NP_032962.1	homeobox protein prophet of Pit-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16678101	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16678101	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16678101	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	16678101	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16678101	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16678101	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	18996108	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12183375	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	18996108	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	12183375	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within hypophysis morphogenesis	IMP IMP: Inferred from mutant phenotype	16678101	MGI
acts upstream of or within hypothalamus cell differentiation	IMP IMP: Inferred from mutant phenotype	9067988	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16556738	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678101	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678101	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	11731482	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678101	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16678101	MGI
acts upstream of or within somatotropin secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	6194978	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16678101	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein prophet of Pit-1

Ames dwarf	pituitary specific homeodomain factor
prophet of Pit-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W039899	1,2,3,4,6-Penta-O-acetyl-D-mannopyranose, 97%		99.79%	Unkown
HY-W583812	Cbz-PEG2-prop-1-yne		/	Unkown
HY-W251756	3-(2-Iodoethoxy)prop-1-yne		/	Unkown
HY-W583811	Cbz-PEG3-prop-1-yne		/	Unkown
HY-W784556	5'-DMTr-dU(Allylamine-CO-F3)-3'-CE-phosphoramidite		/	Unkown
HY-N17408	(E)-2-(2-Hydroxy-4-methylpheny1)-prop-l-en-1-yl acetate		/	Unkown
HY-RS11200	PROP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W784553	Amino-modifier-C6-dC CEP		/	Unkown
HY-W784554	5'-DMTr-Amino-modifier-C6-dT-3'-CE-phosphoramidite		/	Unkown
HY-W784555	5'-DMTr-TFA-ap-dU-3'-CE-Phosphoramidite		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prop1	NCBI	NCBI:5626

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