Pex5 - peroxisomal biogenesis factor 5 Gene

Also Known as Pxr1; ESTM1; PTS1R; PXR1P; PTS1-BP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19305

Summary

Predicted to enable several functions, including peroxisome targeting sequence binding activity; protein C-terminus binding activity; and protein sequestering activity. Involved in protein import into peroxisome matrix. Acts upstream of or within several processes, including fatty acid metabolic process; mitochondrial membrane organization; and nervous system development. Predicted to be located in Golgi apparatus; membrane; and peroxisomal matrix. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and peroxisomal membrane. Is expressed in genitourinary system; inner ear; liver; and nervous system. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Pex5 Products (8)

mRNA Protein Name
NM_001277330.2 NP_001264259.1 peroxisomal targeting signal 1 receptor isoform 2
NM_001277805.2 NP_001264734.1 peroxisomal targeting signal 1 receptor isoform 1
NM_001360570.2 NP_001347499.1 peroxisomal targeting signal 1 receptor isoform 2
NM_001410279.1 NP_001397208.1 peroxisomal targeting signal 1 receptor isoform 1
NM_001410280.1 NP_001397209.1 peroxisomal targeting signal 1 receptor isoform 1
NM_001410281.1 NP_001397210.1 peroxisomal targeting signal 1 receptor isoform 3
NM_008995.3 NP_033021.2 peroxisomal targeting signal 1 receptor isoform 1
NM_175933.3 NP_787947.1 peroxisomal targeting signal 1 receptor isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell development IMP
IMP: Inferred from mutant phenotype
9288097 MGI
acts upstream of or within cellular lipid metabolic process IMP
IMP: Inferred from mutant phenotype
16484321 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: Inferred from mutant phenotype
9288097 MGI
acts upstream of or within cerebral cortex neuron differentiation IMP
IMP: Inferred from mutant phenotype
9288097 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
15732085 MGI
acts upstream of or within fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
9288097 MGI
NOT acts upstream of or within isoprenoid biosynthetic process IMP
IMP: Inferred from mutant phenotype
11420171 MGI
acts upstream of or within mitochondrial membrane organization IMP
IMP: Inferred from mutant phenotype
11583975 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
15732085 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
9288097 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
9288097 MGI
acts upstream of or within peroxisome organization IDA
IDA: Inferred from direct assay
14586000 MGI
acts upstream of or within peroxisome organization IMP
IMP: Inferred from mutant phenotype
9288097 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
9288097 MGI
involved in protein import into peroxisome matrix IMP
IMP: Inferred from mutant phenotype
11463335 MGI
acts upstream of or within very long-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
10653000 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxisomal targeting signal 1 receptor

  • PTS1 receptor

  • peroxin 5

  • peroxisomal C-terminal targeting signal import receptor

  • peroxisome biogenesis factor 5

  • peroxisome receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155530 PEX5-PEX14 PPI-IN-1 / Unkown
HY-155531 PEX5-PEX14 PPI-IN-2 / Unkown
HY-RS10351 PEX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10352 PEX5L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175517 PEX5-PEX14 PPI-IN-3 Inhibitor / Unkown
HY-182443 PEX5-PEX14 PPI-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pex5 NCBI NCBI:5830