Rps6ka1 - ribosomal protein S6 kinase polypeptide 1 Gene

Also Known as Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20111

About Rps6ka1

Chromosome 4: 133,574,601-133,615,108 reverse strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 218 orthologues, 7 paralogues and is associated with 2 phenotypes. Broad expression in duodenum adult (RPKM 79.7), colon adult (RPKM 69.8) and 24 other tissues.

Summary

Enables kinase activity. Involved in hepatocyte proliferation. Located in spindle. Is expressed in central nervous system; early conceptus; oocyte; and retina. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6ka1 Products (4)

mRNA Protein Name
NM_001285505.1 NP_001272434.1 ribosomal protein S6 kinase alpha-1 isoform b
NM_001285506.1 NP_001272435.1 ribosomal protein S6 kinase alpha-1 isoform c
NM_001378880.1 NP_001365809.1 ribosomal protein S6 kinase alpha-1 isoform d
NM_009097.5 NP_033123.2 ribosomal protein S6 kinase alpha-1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10635333 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
10635333 MGI
Biological Process GO Annotation Evidence References Source
involved in hepatocyte proliferation IDA
IDA: Inferred from direct assay
10635333 MGI
Cellular Component GO Annotation Evidence References Source
located in spindle IDA
IDA: Inferred from direct assay
15509711 MGI
is active in synapse EXP
EXP: Inferred from Experiment
25211037 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25211037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6ka1 Protein Structure

STKc_RSK_N

STKc_RSK_N: cd05582 (65 - 381)

STKc_RSK1_C

STKc_RSK1_C: cd14175 (415 - 705)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-1

  • 90 kDa ribosomal protein S6 kinase 1

  • MAP kinase-activated protein kinase 1a

  • MAPK-activated protein kinase 1a

  • MAPKAP kinase 1a

  • ribosomal protein S6 kinase, 90kD, polypeptide 1

  • Ribosomal protein S6 kinase, 90kD, 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123919 TL13-112 Inhibitor 98.01% Unkown
HY-122582 TL13-12 Degrader 98.16% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-RS12248 RPS6KA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12249 Rps6ka1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12250 Rps6ka1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6ka1 NCBI NCBI:6195