AKT2 - AKT serine/threonine kinase 2 Gene

Also Known as PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 208

About AKT2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,230,317-40,285,345 (from NCBI)

This gene has 44 transcripts (splice variants), 237 orthologues, 5 paralogues and is associated with 83 phenotypes. Ubiquitous expression in thyroid (RPKM 30.9), fat (RPKM 28.8) and 25 other tissues.

Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of Cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in Insulin signaling. [provided by RefSeq, Nov 2019]

AKT2 Products (16)

mRNA	Protein	Name
XM_047438400.1	XP_047294356.1	RAC-beta serine/threonine-protein kinase isoform X2
NM_001243028.3	NP_001229957.1	RAC-beta serine/threonine-protein kinase isoform 2
XM_047438403.1	XP_047294359.1	RAC-beta serine/threonine-protein kinase isoform X4
NM_001330511.1	NP_001317440.1	RAC-beta serine/threonine-protein kinase isoform 4
NM_001626.6	NP_001617.1	RAC-beta serine/threonine-protein kinase isoform 1
XM_011526618.2	XP_011524920.1	RAC-beta serine/threonine-protein kinase isoform X2
XM_047438402.1	XP_047294358.1	RAC-beta serine/threonine-protein kinase isoform X3
XM_047438401.1	XP_047294357.1	RAC-beta serine/threonine-protein kinase isoform X2
XM_011526614.2	XP_011524916.1	RAC-beta serine/threonine-protein kinase isoform X2
XM_047438399.1	XP_047294355.1	RAC-beta serine/threonine-protein kinase isoform X2
XM_047438397.1	XP_047294353.1	RAC-beta serine/threonine-protein kinase isoform X1
XM_047438398.1	XP_047294354.1	RAC-beta serine/threonine-protein kinase isoform X1
XM_011526615.2	XP_011524917.1	RAC-beta serine/threonine-protein kinase isoform X2
XM_011526616.2	XP_011524918.1	RAC-beta serine/threonine-protein kinase isoform X2
NM_001243027.3	NP_001229956.1	RAC-beta serine/threonine-protein kinase isoform 2
XM_011526619.2	XP_011524921.1	RAC-beta serine/threonine-protein kinase isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16540465	GOA
enables molecular function activator activity	EXP EXP: Inferred from Experiment	12517337	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10490823	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10983986	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in negative regulation of long-chain fatty acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in positive regulation of cap-dependent translational initiation	IMP IMP: Inferred from mutant phenotype	23444369	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25428377	GOA
involved in positive regulation of cell motility	IMP IMP: Inferred from mutant phenotype	17332325	GOA
involved in positive regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in positive regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in positive regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	16814735	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23444369	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23444369	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20059950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKT2 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
481 a.a.

Protein Preferred Names	Protein Names
RAC-beta serine/threonine-protein kinase	PKB beta RAC-PK-beta murine thymoma viral (v-akt) homolog-2 protein kinase Akt-2 protein kinase B beta putative v-akt murine thymoma viral oncoprotein 2 rac protein kinase beta v-akt murine thymoma viral oncogene homolog 2

AKT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKT2	P31751	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	AKT2	P31751	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	AKT2	P31751	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	AKT2	P31751	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	AKT2	P31751	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	AKT2	P31751	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	AKT2	P31751	UBE2O	Homo sapiens	Q9C0C9	Anti Tag CoIP	33961781
Intra	AKT2	P31751	UBE2O	Homo sapiens	Q9C0C9	Anti Tag CoIP	28514442
Intra	AKT2	P31751	TTC3	Homo sapiens	P53804	Anti Bait CoIP	20059950
Intra	AKT2	P31751	TTC3	Homo sapiens	P53804	Anti Tag CoIP	20059950
Intra	AKT2	P31751	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	AKT2	P31751	VIM	Homo sapiens	P08670	Anti Bait CoIP	20856200
Intra	AKT2	P31751	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	AKT2	P31751	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	AKT2	P31751	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	AKT2	P31751	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	AKT2	P31751	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AKT2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74420	AKT2 Protein, Human (sf9, His-GST)	P31751 (M1-E481)	≥ 90%, as determined by reducing SDS-PAGE.

AKT2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80535	AKT1+AKT2+AKT3 Antibody (YA635)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
HY-P80535A	AKT1+AKT2+AKT3 Antibody (YA635)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
HY-P810595	Phospho-AKT2 (Ser474) Antibody	WB, IHC-P	Human, Mouse
HY-P810596	Phospho-AKT2 (Ser474) Antibody (YA9859)	WB, FC	Human, Mouse, Rat
HY-P84255	AKT2 Antibody (YA3952)	WB, IHC-P, ICC/IF, ELISA	Human, Rat, Monkey
HY-P84255A	AKT2 Antibody (YA3952)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Rat, Monkey
HY-P85759	AKT Antibody (YA5451)	WB, IP, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86145	Phospho-AKT(Thr308) Antibody (YA5837) (YA5837)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86312	AKT1/2/3 Antibody (YA6004)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86450	Phospho-AKT(Ser473) Antibody (YA6142) (YA6142)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lipodystrophy, Familial Partial, Type 6	FPLD6 Lipe-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 6 Lipe-Related Fpld Lipodystrophy, Familial Partial, Associated With Lipe Mutations Familial Partial Lipodystrophy Associated With Lipe Mutations Lipodystrophy, Familial Partial, 6
Acute Dacryoadenitis
Cowden Syndrome 1	Pten Hamartoma Tumor Syndrome Bannayan-Riley-Ruvalcaba Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Lhermitte-Duclos Syndrome Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Akt2-Related Familial Partial Lipodystrophy	Akt2-Related Fpld
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Premature Ovarian Failure 19	POF19 Primary Ovarian Insufficiency 19 Poi19 Ovarian Failure, Premature, Type 19
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Lipodystrophy, Familial Partial, Type 3	FPLD3 Pparg-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 3 Familial Partial Lipodystrophy Associated With Pparg Mutations Pparg-Related Fpld Lipodystrophy, Familial Partial, Associated With Pparg Mutations Insulin Resistance, Severe, Digenic Lipodystrophy, Familial Partial, 3 Familial Partial Lipodystrophy, Type 3
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Donohue Syndrome	Leprechaunism Leprechaunism Syndrome Donohue'S Syndrome LEPRCH
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Complete Generalized Lipodystrophy
Diabetes Mellitus	Diabetes
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Autosomal Dominant Intellectual Developmental Disorder 19	Autosomal Dominant Non-Syndromic Intellectual Disability 19 Autosomal Dominant Mental Retardation 19 Mrd19
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi	Cloves Syndrome Clove Syndrome Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities Clove Syndrome, Somatic Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome CLOVE Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities Congenital Arteriovenous Malformation Arteriovenous Hemangioma Nevus Melanocytic Nevus Benign Melanocytic Nevus
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Growth Retardation With Sensorineural Deafness And Mental Retardation Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Hypoinsulinemic Hypoglycemia With Hemihypertrophy	Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy HIHGHH
Lipodystrophy, Familial Partial, Type 2	FPLD2 Lipoatrophic Diabetes Familial Partial Lipodystrophy Type 2 Familial Partial Lipodystrophy, Dunnigan Type Fpl2 Lipoatrophic Diabetes Mellitus Lipodystrophy, Familial Partial, Dunnigan Type Lipodystrophy, Familial, Of Limbs And Lower Trunk Lipodystrophy, Reverse Partial Familial Partial Lipodystrophy Dunnigan Type Dunnigan Syndrome Familial Lipodystrophy Of Limbs And Lower Trunk Reverse Partial Lipodystrophy Lipodystrophy, Familial Partial, 2 Generalized Lipoatrophy Associated With Diabetes, Hepatic Steatosis, Hypertrophic Cardiomyopathy And Leukomelanodermic Papules Lipodystrophy Familial Of Limbs And Lower Trunk Lipodystrophy Reverse Partial Diabetes Mellitus, Lipoatrophic Familial Partial Lipodystrophy, Type 2 Familial Generalized Lipodystrophy
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0960	Sulfabenzamide		99.68%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99118	Serplulimab	Inducer	99.30%	Unkown

Clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15186	Ipatasertib	Inhibitor	99.88%	Phase 4
HY-N0004	Oridonin	Inhibitor	99.89%	Phase 4
HY-15431	Capivasertib	Inhibitor	99.96%	Phase 3
HY-15727	Afuresertib	Inhibitor	99.53%	Phase 3
HY-15186A	Ipatasertib dihydrochloride	Inhibitor	99.27%	Phase 3
HY-19719	Miransertib	Inhibitor	99.32%	Phase 2
HY-15965	Uprosertib	Inhibitor	99.93%	Phase 2
HY-19934A	Pifusertib hydrochloride	Inhibitor	99.90%	Phase 2
HY-15727A	Afuresertib hydrochloride	Inhibitor	99.95%	Phase 2
HY-19719A	Miransertib hydrochloride	Inhibitor	99.74%	Phase 2
HY-19934	Pifusertib	Inhibitor	99.81%	Phase 2
HY-15965A	Uprosertib hydrochloride	Inhibitor	/	Phase 2
HY-10358	MK-2206 dihydrochloride	Inhibitor	99.99%	Phase 1
HY-10249	GSK-690693	Inhibitor	99.03%	Phase 1
HY-100018	BAY1125976	Inhibitor	99.52%	Phase 1
HY-16071	AT13148	Inhibitor	99.20%	Phase 1
HY-15186C	Ipatasertib tosylate	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10355	AKT inhibitor VIII	Inhibitor	98.97%	Unkown
HY-108232	MK-2206	Inhibitor	99.72%	Unkown
HY-10425	Rizavasertib	Inhibitor	99.04%	Unkown
HY-133120	INY-03-041	Inhibitor	99.74%	Unkown
HY-13260	CCT128930	Inhibitor	99.69%	Unkown
HY-151504	Engasertib	Inhibitor	99.65%	Unkown
HY-12059	AT7867	Inhibitor	99.85%	Unkown
HY-137458A	Vevorisertib trihydrochloride	Inhibitor	98.05%	Unkown
HY-19982	AKT-IN-6	Inhibitor	99.08%	Unkown
HY-50862	Akt1/Akt2-IN-1	Inhibitor	99.30%	Unkown
HY-145282	MS170	Inhibitor	98.68%	Unkown
HY-12059A	AT7867 dihydrochloride	Inhibitor	99.73%	Unkown
HY-137458	Vevorisertib	Inhibitor	98.03%	Unkown
HY-133120A	INY-03-041 trihydrochloride	Inhibitor	99.78%	Unkown
HY-132302	Hu7691	Inhibitor	99.91%	Unkown
HY-13260A	CCT128930 hydrochloride	Inhibitor	98.97%	Unkown
HY-16666	3CAI	Inhibitor	98.32%	Unkown
HY-129119	Akt1/Akt2-IN-2	Inhibitor	98.57%	Unkown
HY-151613	MS15	Inhibitor	/	Unkown
HY-126257	AKT-IN-3	Inhibitor	98.12%	Unkown
HY-145281	MS98	Inhibitor	/	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-10357	MK-2206 free base	Inhibitor	/	Unkown
HY-138767	AKT-IN-5	Inhibitor	/	Unkown
HY-143611	AKT-IN-8	Inhibitor	/	Unkown
HY-16032	Akt1-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AKT2	VGNC	VGNC:69777
Bos taurus	AKT2	VGNC	VGNC:25799
Mus musculus	AKT2	MGD	MGI:104874
Rattus norvegicus	AKT2	RGD	RGD:2082
Canis familiaris	AKT2	VGNC	VGNC:37772
Felis catus	AKT2	VGNC	VGNC:59728
Others	AKT2	NCBI