Cat. No.: HY-129119

Akt1/Akt2-IN-2

Customer Review

Based on 1 Customer Validation

Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC₅₀=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells.

For research use only. We do not sell to patients.

Purity: 96.01%
CAS No.: 612847-42-4
Formula: C₄₀H₄₃N₇O₂
Molecular Weight:653.82

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Akt1/Akt2-IN-2 Chemical Structure

CAS No.: 612847-42-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Akt1

138 nM (IC₅₀)

Akt2

212 nM (IC₅₀)

Akt3

7.2 mM (IC₅₀)

Caspase-3

All Akt Isoforms :

All Caspase Isoforms :

In Vitro

Akt1/Akt2-IN-2 (compound 7) has cytotoxicity against LnCaP, HT29, MCF7, and A2780 cells^[1].
Akt1/Akt2-IN-2 (2 μM, 4 μM) induces caspase-3 activity up to 3 or 6.6 fold increases in LnCaP cells, at 2 μM and 4 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 612847-42-4
Appearance Solid
Molecular Weight 653.82
Formula C₄₀H₄₃N₇O₂
Color Off-white to light yellow
SMILES

O=C(C1=CC=C2N=C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC(N6C7=CC=CC=C7NC6=O)CC5)C=C4)=NC2=C1)NCCN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (191.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 18 mg/mL (27.53 mM; Need ultrasonic and warming)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5295 mL

7.6474 mL

15.2947 mL

5 mM

0.3059 mL

1.5295 mL

3.0589 mL

10 mM

0.1529 mL

0.7647 mL

1.5295 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.5295 mL	7.6474 mL	15.2947 mL	38.2368 mL
	5 mM	0.3059 mL	1.5295 mL	3.0589 mL	7.6474 mL
	10 mM	0.1529 mL	0.7647 mL	1.5295 mL	3.8237 mL
	15 mM	0.1020 mL	0.5098 mL	1.0196 mL	2.5491 mL
	20 mM	0.0765 mL	0.3824 mL	0.7647 mL	1.9118 mL
	25 mM	0.0612 mL	0.3059 mL	0.6118 mL	1.5295 mL
DMSO	30 mM	0.0510 mL	0.2549 mL	0.5098 mL	1.2746 mL
	40 mM	0.0382 mL	0.1912 mL	0.3824 mL	0.9559 mL
	50 mM	0.0306 mL	0.1529 mL	0.3059 mL	0.7647 mL
	60 mM	0.0255 mL	0.1275 mL	0.2549 mL	0.6373 mL
	80 mM	0.0191 mL	0.0956 mL	0.1912 mL	0.4780 mL
	100 mM	0.0153 mL	0.0765 mL	0.1529 mL	0.3824 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Akt1/Akt2-IN-2

Bioactive Compound Library Max

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Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

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Pain-Related Compound Library

Highly Selective Inhibitors Library

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Multi-Target Compound Library

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Anti-Fibrosis Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

All Akt Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Akt1/Akt2-IN-2 Related Classifications

HY-129119 Related Classifications