612847-42-4
Chemical Structure
Akt1/Akt2-IN-2
- CAS No.: 612847-42-4
- Formula:C40H43N7O2
- Molecular Weight:653.82
IUPAC Name: N-(2-(diethylamino)ethyl)-3-(4-((4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)-2-phenylquinoxaline-6-carboxamide
InChIKey: HBCHTLGWXPVWDF-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC(N6C7=CC=CC=C7NC6=O)CC5)C=C4)=NC2=C1)NCCN(CC)CC
Biological Activity: Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
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Akt1/Akt2-IN-2 | 96.01% | Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells. | ||||||||||||||||||||
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Keywords