Tcl1 - T cell lymphoma breakpoint 1 Gene

Also Known as Tcl1a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21432

Summary

Predicted to enable identical protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in activation of protein kinase B activity. Acts upstream of or within negative regulation of gene expression; regulation of stem cell population maintenance; and stem cell population maintenance. Located in cell cortex and pronucleus. Is expressed in several structures, including early conceptus; hemolymphoid system gland; liver; and seminiferous cord. Orthologous to human TCL1A (TCL1 family Akt coactivator A). [provided by Alliance of Genome Resources, Apr 2022]

Tcl1 Products (4)

mRNA Protein Name
NM_001289468.1 NP_001276397.1 T-cell leukemia/lymphoma protein 1A isoform 2
NM_001309484.1 NP_001296413.1 T-cell leukemia/lymphoma protein 1A isoform 3
NM_001309485.1 NP_001296414.1 T-cell leukemia/lymphoma protein 1A isoform 4
NM_009337.3 NP_033363.1 T-cell leukemia/lymphoma protein 1A isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in activation of protein kinase B activity IMP
IMP: Inferred from mutant phenotype
28262547 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17938240 MGI
acts upstream of or within regulation of stem cell population maintenance IGI
IGI: Inferred from genetic interaction
17938240 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
16767105 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
12181493 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12181493 MGI
located in ooplasm IDA
IDA: Inferred from direct assay
12181493 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
12181493 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell leukemia/lymphoma protein 1A

  • TCL-1

  • oncogene TCL-1

  • oncogene TCL1

  • protein p14 TCL1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18676B ILK-IN-2 99.41% Unkown
HY-N8177 Bletilloside A Inhibitor 99.88% Unkown
HY-159808 TCL1 Inhibitor / Unkown
HY-P10049 TAT-TCL1-Akt-in Inhibitor / Unkown
HY-P10105 TCL1(10-24) Inhibitor / Unkown
HY-RS14316 TCL1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14317 TCL1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25978 Tcl1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990242 Anti-Mouse Galectin-9 Antibody (RG9-1) Inhibitor 95.64% Unkown