Ascl5 - achaete-scute family bHLH transcription factor 5 Gene

Mus musculus

Also known as Gm197; AmeloD; bHLHa47; Ascl5-ps

Gene ID: 226439 | Gene type: protein coding

About Ascl5

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in genitourinary system; oral region epithelium; and tooth. Orthologous to human ASCL5 (achaete-scute family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Ascl5 Products(1)

mRNA	Protein	Name
NM_001270609.2	NP_001257538.1	achaete-scute homolog 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	30426815	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	30426815	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	30426815	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	30426815	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ameloblast differentiation	IMP IMP: Inferred from mutant phenotype	30504223	MGI
involved in amelogenesis	IMP IMP: Inferred from mutant phenotype	30504223	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	30426815	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	30426815	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	30426815	MGI
located in chromatin	IDA IDA: Inferred from direct assay	30426815	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

achaete-scute homolog 5

achaete-scute complex homolog 5, pseudogene

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01082	ASCL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ascl5	NCBI	NCBI:647219

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