Atp2c1 - ATPase, Ca++-sequestering Gene

Also Known as HHD; BCPM; SPCA; pmr1; SPCA1; ATP2C1A; 1700121J11Rik; D930003G21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235574

Summary

Predicted to enable ATP binding activity; ATPase-coupled cation transmembrane transporter activity; and metal ion binding activity. Involved in Golgi calcium ion homeostasis and positive regulation of Golgi to plasma membrane protein transport. Located in Golgi cisterna membrane and cis-Golgi network membrane. Is expressed in several structures, including gut; heart; liver; lung; and mammary gland. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Orthologous to human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2c1 Products (6)

mRNA Protein Name
NM_001253831.1 NP_001240760.1 calcium-transporting ATPase type 2C member 1 isoform 1
NM_001253834.1 NP_001240763.1 calcium-transporting ATPase type 2C member 1 isoform 2
NM_001253836.1 NP_001240765.1 calcium-transporting ATPase type 2C member 1 isoform 3
NM_001359822.1 NP_001346751.1 calcium-transporting ATPase type 2C member 1 isoform 4
NM_001359823.1 NP_001346752.1 calcium-transporting ATPase type 2C member 1 isoform 5
NM_175025.4 NP_778190.3 calcium-transporting ATPase type 2C member 1 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in Golgi calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
19793975 MGI
involved in positive regulation of Golgi to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
19793975 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
23840669 MGI
located in Golgi cisterna membrane IDA
IDA: Inferred from direct assay
19793975 MGI
located in cis-Golgi network membrane IDA
IDA: Inferred from direct assay
19793975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium-transporting ATPase type 2C member 1

  • ATP-dependent Ca(2+) pump PMR1

  • ATPase 2C1

  • ATPase, Ca++ transporting, type 2C, member 1

  • Ca(2+)/Mn(2+)-ATPase 2C1

  • secretory pathway Ca(2+)-transporting ATPase type 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01198 ATP2C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2c1 NCBI NCBI:27032