TMEFF2 - transmembrane protein with EGF like and two follistatin like domains 2 Gene

Also Known as TR; HPP1; TPEF; TR-2; TENB2; CT120.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23671

About TMEFF2

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,949,046-192,194,933 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 27 paralogues. Biased expression in prostate (RPKM 5.9), brain (RPKM 4.8) and 3 other tissues.

Summary

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate Cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple Cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEFF2 Products (3)

mRNA Protein Name
NM_001305134.2 NP_001292063.1 tomoregulin-2 isoform 2 precursor
NM_001305145.1 NP_001292074.1 tomoregulin-2 isoform 3 precursor
NM_016192.4 NP_057276.2 tomoregulin-2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
26402097 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within negative regulation of cell migration IDA
IDA: Inferred from direct assay
24632071 GOA
acts upstream of or within negative regulation of integrin biosynthetic process IMP
IMP: Inferred from mutant phenotype
24632071 GOA
acts upstream of or within negative regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
24632071 GOA
acts upstream of or within wound healing, spreading of cells IDA
IDA: Inferred from direct assay
24632071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEFF2 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (95 - 135)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (186 - 227)

hEGF

hEGF: Human growth factor-like EGF (288 - 300)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

tomoregulin-2

  • cancer/testis antigen family 120, member 2

TMEFF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TMEFF2 Q9UIK5 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
TMEFF2 Q9UIK5 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
TMEFF2 Q9UIK5 TRHR Homo sapiens P34981
Y2H Prey Pooling
32296183
Intra
TMEFF2 Q9UIK5 TRHR Homo sapiens P34981
Y2H Array
32296183
Intra
TMEFF2 Q9UIK5 P05067-PRO_0000000090 Homo sapiens P05067-PRO_0000000090
Pull Down
26402097
Intra
TMEFF2 Q9UIK5 P05067-PRO_0000000090 Homo sapiens P05067-PRO_0000000090
Anti Bait CoIP
26402097
Intra
TMEFF2 Q9UIK5 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
TMEFF2 Q9UIK5 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
TMEFF2 Q9UIK5 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra
TMEFF2 Q9UIK5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
TMEFF2 Q9UIK5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMEFF2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P700470 TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) Q9UIK5 (F41-V320) ≥ 95%, as determined by reducing SDS-PAGE.

TMEFF2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82290 Tomoregulin 2 Antibody (YA2035) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P990692 Ciduvectamig Inhibitor 95.879% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14642 TMEFF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21206 Tmeff2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27722 Tmeff2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990523 Anti-TMEFF2 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEFF2 RGD RGD:1308839
Mus musculus TMEFF2 MGD MGI:1861735
Canis familiaris TMEFF2 VGNC VGNC:47442
Bos taurus TMEFF2 VGNC VGNC:35940
Macaca mulatta TMEFF2 VGNC VGNC:78569
Felis catus TMEFF2 VGNC VGNC:66252
Others TMEFF2 NCBI