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  5. Tomoregulin 2 Antibody (YA2035)

Tomoregulin 2 Antibody (YA2035)

Cat. No.: HY-P82290
User Guide for Antibodies Technical Support

Tomoregulin 2 Antibody (YA2035) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tomoregulin 2.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
50 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
100 μL Get quote 3 - 4 Weeks 2 - 3 Weeks 4 - 5 Weeks 3 - 4 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Tomoregulin 2 Antibody (YA2035) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tomoregulin 2.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 41 kDa;
Observed band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human TMEFF2 aa350-374.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation
Subcellular Localization：Membrane; Single-pass type I membrane protein; Membrane; Single-pass type I membrane protein; Secreted
Expression：
Tissue_specificity:Highly expressed in human brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level) . Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate

Induction:Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines
Isoforms & Post-Translational Modification：Q9UIK5 has 3 isomers: Q9UIK5-1: 41428 Da (predicted); Q9UIK5-2: 38132 Da (predicted); Q9UIK5-3: 19472 Da (predicted).
O-glycosylated; contains chondroitin sulfate glycosaminoglycans;A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17
Database

Entrez Gene: 23671 Human

SwissProt: Q9UIK5 Human

OMIM: 605734 Human

Research Field

Cancer
Synonyms
TMEFF2; HPP1; TPEF; TR-2; Tomoregulin; TENB2; Tomoregulin-2; CT120.2
Documentation
User Guide for Antibodies (1077 KB)

Tomoregulin 2 Antibody (YA2035) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tomoregulin 2 Antibody (YA2035)
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