Tomoregulin 2 Antibody (YA2035)
(Synonyms: TMEFF2; HPP1; TPEF; TR-2; Tomoregulin; TENB2; Tomoregulin-2; CT120.2)Tomoregulin 2 Antibody (YA2035) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tomoregulin 2.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, ICC/IF, FC
-
Reactivity :
Human
-
Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:200 | 1:50-1:100 |
Product Details
Tomoregulin 2 Antibody (YA2035) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tomoregulin 2.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 41 kDa
A synthesized peptide derived from human TMEFF2 aa350-374.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Tomoregulin 2 may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation
-
Subcellular Localization
Membrane; Single-pass type I membrane protein; Membrane; Single-pass type I membrane protein; Secreted
-
Expression
Tissue_specificity:Highly expressed in human brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level) . Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate
Induction:Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines -
Isoforms & Post-Translational Modification
Q9UIK5 has 3 isomers: Q9UIK5-1: 41428 Da (predicted); Q9UIK5-2: 38132 Da (predicted); Q9UIK5-3: 19472 Da (predicted).
O-glycosylated; contains chondroitin sulfate glycosaminoglycans;A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17 -
SwissProt ID
-
Synonyms
TMEFF2; HPP1; TPEF; TR-2; Tomoregulin; TENB2; Tomoregulin-2; CT120.2
-
Research Field
Cancer
Documentation
Powered by Bioz
