Nqo1 - NAD(P)H quinone dehydrogenase 1 Gene

Also Known as Dia4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24314

Summary

Enables NAD(P)H dehydrogenase (quinone) activity and superoxide dismutase activity. Involved in several processes, including NADPH oxidation; regulation of apoptotic process; and response to ischemia. Located in cytosol; dendrite; and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including brain disease (multiple); chronic obstructive pulmonary disease; fatty liver disease (multiple); prostatitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic Cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nqo1 Products (2)

mRNA Protein Name
NM_017000.3 NP_058696.2 NAD(P)H dehydrogenase [quinone] 1
NM_017000.3 NP_058696.2 NAD(P)H dehydrogenase [quinone] 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD(P)H dehydrogenase (quinone) activity IDA
IDA: Inferred from direct assay
12603827 RGD
enables NADH:ubiquinone reductase (non-electrogenic) activity IDA
IDA: Inferred from direct assay
8999809 RGD
enables superoxide dismutase activity IMP
IMP: Inferred from mutant phenotype
17901563 RGD
Biological Process GO Annotation Evidence References Source
involved in NADH oxidation IDA
IDA: Inferred from direct assay
29389585 RGD
involved in NADPH oxidation IDA
IDA: Inferred from direct assay
29444417 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
28271112 RGD
involved in cellular response to metal ion IEP
IEP: Inferred from expression pattern
28722058 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
22227174 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
12603827 RGD
involved in response to L-glutamine IDA
IDA: Inferred from direct assay
30967905 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
31432116 RGD
involved in response to amine IDA
IDA: Inferred from direct assay
29444417 RGD
involved in response to carbohydrate IEP
IEP: Inferred from expression pattern
31933629 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
28887183 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
14672740 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20833713 RGD
involved in response to flavonoid IEP
IEP: Inferred from expression pattern
31399183 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
30483575 RGD
involved in response to hydrogen sulfide IEP
IEP: Inferred from expression pattern
29054567 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
31399183 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
21092375 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
21549141 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
12011483 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
31819135 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
30483575 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
30967905 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
29091898 RGD
involved in superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
17901563 RGD
involved in vitamin K metabolic process IDA
IDA: Inferred from direct assay
8999809 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
28322084 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
14991562 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD(P)H dehydrogenase [quinone] 1

  • DT-diaphorase

  • DTD

  • Diaphorase (NADH/NADPH)

  • NAD(P)H dehydrogenase, quinone 1

  • NAD(P)H:menadione oxidoreductase

  • NAD(P)H:quinone oxidoreductase 1

  • QR1

  • azoreductase

  • menadione reductase

  • phylloquinone reductase

  • quinone reductase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141439 TBE 31 Inducer / Unkown
HY-181017 Ola-NC-SS-PEG-Lap / Unkown
HY-D3209 NIR-ASM / Unkown
HY-170947 Antitumor agent-195 Inhibitor / Unkown
HY-180155 Keap1/Nrf2/ARE activator 2 Activator / Unkown
HY-183692 FXR agonist 18 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nqo1 NCBI NCBI:1728
Mus musculus Nqo1 NCBI NCBI:18104