2. Immunology/Inflammation NF-κB Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) DNA/RNA Synthesis PARP Quinone Reductase
  4. Ola-NC-SS-PEG-Lap

Ola-NC-SS-PEG-Lap is a selective immunogenic cell death inducer. Ola-NC-SS-PEG-Lap exploits the synergistic interplay between an NQO1-bioactivated compound and a PARP inhibitor to selectively induce immunogenic cell death in tumor cells without harming normal cells. Ola-NC-SS-PEG-Lap induces ROS accumulation, increases DNA damage. Ola-NC-SS-PEG-Lap can be activated by GSH and release Ola, ultimately producing the synergistic antitumor effect with the Lap portion. Ola-NC-SS-PEG-Lap has anti-cancer activity against colon cancer.

For research use only. We do not sell to patients.

Ola-NC-SS-PEG-Lap

Ola-NC-SS-PEG-Lap Chemical Structure

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Ola-NC-SS-PEG-Lap Related Antibodies

Top Publications Citing Use of Products

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

View All PARP Isoform Specific Products:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Ola-NC-SS-PEG-Lap is a selective immunogenic cell death inducer. Ola-NC-SS-PEG-Lap exploits the synergistic interplay between an NQO1-bioactivated compound and a PARP inhibitor to selectively induce immunogenic cell death in tumor cells without harming normal cells. Ola-NC-SS-PEG-Lap induces ROS accumulation, increases DNA damage. Ola-NC-SS-PEG-Lap can be activated by GSH and release Ola, ultimately producing the synergistic antitumor effect with the Lap portion. Ola-NC-SS-PEG-Lap has anti-cancer activity against colon cancer[1].

IC50 & Target[1]

NQO1

 

Molecular Weight

1147.25

Formula

C55H63FN6O16S2
SMILES

O=C1N(N=C(C2=CC=CC=C21)CC3=CC=C(C(C(N4CCN(CC4)C(C5CC5)=O)=O)=C3)F)CNC(OCCSSCCOC(NCCOCCOCCOCCOC(OC6CC7=C(C8=CC=CC=C8C(C7=O)=O)OC6(C)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ola-NC-SS-PEG-Lap Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ola-NC-SS-PEG-LapReactive Oxygen Species (ROS)DNA/RNA SynthesisPARPQuinone Reductasepoly ADP ribose polymerase anti-cancerMC38Inhibitorinhibitorinhibit

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