Tnnt2 - troponin T2, cardiac type Gene

Also Known as Ctt; CTTG; Tnnt3; RATCTTG

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24837

Summary

Enables protein-macromolecule adaptor activity and troponin I binding activity. Involved in actin crosslink formation; cardiac muscle contraction; and regulation of muscle filament sliding speed. Located in myofibril. Part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]

Tnnt2 Products (1)

mRNA Protein Name
NM_012676.1 NP_036808.1 troponin T, cardiac muscle

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12501194 RGD
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
16443664 RGD
enables troponin I binding IPI
IPI: Inferred from physical interaction
12501194 RGD
Biological Process GO Annotation Evidence References Source
involved in actin crosslink formation IDA
IDA: Inferred from direct assay
16443664 RGD
involved in cardiac muscle contraction IDA
IDA: Inferred from direct assay
11448842 RGD
involved in muscle contraction IMP
IMP: Inferred from mutant phenotype
16644804 RGD
involved in regulation of muscle filament sliding speed IMP
IMP: Inferred from mutant phenotype
10747195 RGD
involved in tissue remodeling IEP
IEP: Inferred from expression pattern
23887904 RGD
Cellular Component GO Annotation Evidence References Source
located in myofibril IDA
IDA: Inferred from direct assay
11448842 RGD
part of troponin complex IDA
IDA: Inferred from direct assay
12501194 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

troponin T, cardiac muscle

  • Troponin T cardiac

  • cTnT

  • cardiac muscle troponin T

  • cardiac troponin T2

  • tnTc

  • troponin T type 2 (cardiac)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14855 TNNT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22869 Tnnt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29383 Tnnt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnnt2 NCBI NCBI:7139
Mus musculus Tnnt2 NCBI NCBI:21956