Gabrb2 - gamma-aminobutyric acid type A receptor subunit beta 2 Gene

Also Known as GARB2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25451

Summary

Enables GABA-A receptor activity; Chloride Channel activity; and inhibitory extracellular ligand-gated ion channel activity. Contributes to GABA Receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in cytosol and membrane. Is integral component of plasma membrane. Part of GABA-A receptor complex. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb2 Products (1)

mRNA Protein Name
NM_012957.2 NP_037089.1 gamma-aminobutyric acid receptor subunit beta-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to GABA receptor activity IDA
IDA: Inferred from direct assay
12930820 RGD
enables GABA-A receptor activity IMP
IMP: Inferred from mutant phenotype
11877425 RGD
enables chloride channel activity IMP
IMP: Inferred from mutant phenotype
18281286 RGD
enables inhibitory extracellular ligand-gated monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
11877425 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
26592470 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
26592470 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11350968 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to histamine IDA
IDA: Inferred from direct assay
18281286 RGD
involved in chloride transmembrane transport IMP
IMP: Inferred from mutant phenotype
18281286 RGD
involved in synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
12930820 RGD
Cellular Component GO Annotation Evidence References Source
part of GABA receptor complex IDA
IDA: Inferred from direct assay
12930820 RGD
part of GABA-A receptor complex IMP
IMP: Inferred from mutant phenotype
18281286 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
15174078 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15174078 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9464994 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
18281286 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
15174078 RGD
located in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9464994 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
15174078 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit beta-2

  • GABA(A) receptor subunit beta-2

  • Gamma-aminobutyric acid receptor beta 2

  • gamma-aminobutyric acid (GABA) A receptor, beta 2

  • gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2

  • gamma-aminobutyric acid type A receptor beta 2 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05216 GABRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21133 Gabrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27651 Gabrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrb2 NCBI NCBI:2561