Scn4a - sodium voltage-gated channel alpha subunit 4 Gene

Also Known as NCHVS; Nav1.4; microI

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25722

About Scn4a

Primary_assembly 10: 91,246,936-91,296,545 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 191 orthologues, 26 paralogues and is associated with 25 phenotypes. Restricted expression toward (RPKM 389.5).

Summary

Predicted to enable voltage-gated Sodium Channel activity. Involved in choline transport; potassium ion transport; and sodium ion transmembrane transport. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4). [provided by Alliance of Genome Resources, Apr 2022]

Scn4a Products (1)

mRNA Protein Name
NM_013178.2 NP_037310.2 sodium channel protein type 4 subunit alpha

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in choline transport IMP
IMP: Inferred from mutant phenotype
20926383 RGD
involved in monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
20926383 RGD
involved in potassium ion transport IMP
IMP: Inferred from mutant phenotype
20926383 RGD
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
16303569 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
20926383 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16303569 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn4a Protein Structure

Ion_trans

Ion_trans: pfam00520 (129 - 450)

Ion_trans

Ion_trans: pfam00520 (570 - 783)

Na_trans_assoc

Na_trans_assoc: pfam06512 (809 - 1018)

Ion_trans

Ion_trans: pfam00520 (1022 - 1296)

Na_channel_gate

Na_channel_gate: cd13433 (1288 - 1340)

Ion_trans

Ion_trans: pfam00520 (1345 - 1601)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1840 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 4 subunit alpha

  • Sodium channel voltage-gated type IV alpha polypeptide

  • mu-1

  • skM1

  • sodium channel protein skeletal muscle subunit alpha

  • sodium channel protein type IV subunit alpha

  • sodium channel, voltage-gated, type 4, alpha polypeptide

  • sodium channel, voltage-gated, type 4, alpha subunit

  • sodium channel, voltage-gated, type IV, alpha polypeptide

  • sodium channel, voltage-gated, type IV, alpha subunit

  • voltage-gated sodium channel subunit alpha Nav1.4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12537 SCN4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12538 Scn4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12539 Scn4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn4a NCBI NCBI:6329