Pclo - piccolo (presynaptic cytomatrix protein) Gene

Also Known as Acz; Pico

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26875

Summary

Enables profilin binding activity. A structural constituent of presynaptic active zone. Involved in presynapse to nucleus signaling pathway; protein localization to synapse; and synaptic vesicle clustering. Acts upstream of or within Cytoskeleton organization; Insulin secretion; and regulation of exocytosis. Located in postsynaptic density and presynaptic active zone cytoplasmic component. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Pclo Products (2)

mRNA Protein Name
NM_001110796.2 NP_001104266.1 protein piccolo isoform 2
NM_011995.4 NP_036125.4 protein piccolo isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables profilin binding IDA
IDA: Inferred from direct assay
10508862 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12401793 MGI
enables structural constituent of presynaptic active zone IDA
IDA: Inferred from direct assay
26793095 MGI
enables structural constituent of presynaptic active zone IMP
IMP: Inferred from mutant phenotype
26793095 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytoskeleton organization IDA
IDA: Inferred from direct assay
10508862 MGI
acts upstream of or within insulin secretion IDA
IDA: Inferred from direct assay
12401793 MGI
involved in presynaptic actin cytoskeleton organization EXP
EXP: Inferred from Experiment
21976510 MGI
involved in presynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
21976510 MGI
involved in presynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21976510 MGI
involved in protein localization to synapse IGI
IGI: Inferred from genetic interaction
25652077 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: Inferred from direct assay
12401793 MGI
involved in synaptic vesicle clustering IDA
IDA: Inferred from direct assay
20332206 MGI
involved in synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
20332206 MGI
Cellular Component GO Annotation Evidence References Source
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in synapse IDA
IDA: Inferred from direct assay
10508862 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein piccolo

  • aczonin

  • brain-derived HLMN protein

  • multidomain presynaptic cytomatrix protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10155 PCLO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22272 Pclo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28795 Pclo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pclo NCBI NCBI:27445