TMEM176B - transmembrane protein 176B Gene

Also Known as LR8; MS4B2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28959

About TMEM176B

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,791,301-150,801,360 (from NCBI)

This gene has 6 transcripts (splice variants), 93 orthologues and 1 paralogue. Broad expression in liver (RPKM 288.9), kidney (RPKM 126.6) and 16 other tissues.

Summary

Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM176B Products (6)

mRNA Protein Name
NM_001101311.2 NP_001094781.1 transmembrane protein 176B isoform a
NM_001101312.2 NP_001094782.1 transmembrane protein 176B isoform a
NM_001101314.2 NP_001094784.1 transmembrane protein 176B isoform b
NM_001362691.2 NP_001349620.1 transmembrane protein 176B isoform c
NM_001362692.2 NP_001349621.1 transmembrane protein 176B isoform c
NM_014020.4 NP_054739.3 transmembrane protein 176B isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM176B Protein Structure

CD20

CD20: CD20-like family (66 - 228)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

transmembrane protein 176B

  • LR8-like protein

TMEM176B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM176B Q3YBM2 PRKCA Homo sapiens P17252
Validated Y2H
32814053
Intra
TMEM176B Q3YBM2 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
TMEM176B Q3YBM2 PRKCA Homo sapiens P17252
Y2H Array
32814053
Intra
TMEM176B Q3YBM2 TMEM176A Homo sapiens Q96HP8
Y2H Prey Pooling
32296183
Intra
TMEM176B Q3YBM2 TMEM176A Homo sapiens Q96HP8
Y2H Array
32296183
Intra
TMEM176B Q3YBM2 TMEM176A Homo sapiens Q96HP8
Validated Y2H
32296183
Intra
TMEM176B Q3YBM2 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
TMEM176B Q3YBM2 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
TMEM176B Q3YBM2 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
TMEM176B Q3YBM2 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
TMEM176B Q3YBM2 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
TMEM176B Q3YBM2 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
TMEM176B Q3YBM2 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
TMEM176B Q3YBM2 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
TMEM176B Q3YBM2 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14685 TMEM176B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEM176B RGD RGD:708403
Felis catus TMEM176B VGNC VGNC:66293
Mus musculus TMEM176B MGD MGI:1916348
Macaca mulatta TMEM176B VGNC VGNC:79817
Canis familiaris TMEM176B VGNC VGNC:47502
Bos taurus TMEM176B VGNC VGNC:36001