2. Gene
  3. Oprl1 - opioid related nociceptin receptor 1 Gene

Oprl1 - opioid related nociceptin receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as KOR3; OFQR; ORL1; Oprl; XOR1; KOR-3; LC132; MOR-C

Gene ID: 29256 | Gene type: protein coding

About Oprl1

Primary_assembly 3: 168,834,003-168,839,920 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 18 phenotypes. Restricted expression toward (RPKM 14.3).

Summary

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprl1 Products(3)

mRNA Protein Name
NM_001318947.1 NP_001305876.1 nociceptin receptor isoform 1x
NM_001318948.1 NP_001305877.1 nociceptin receptor isoform 2
NM_031569.4 NP_113757.1 nociceptin receptor isoform 1

Oprl1 Protein Structure

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (48 - 326)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (49 - 75)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (82 - 108)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (119 - 149)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (161 - 183)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (208 - 237)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (252 - 282)

7tmA_NOFQ_opioid_R

7tmA_NOFQ_opioid_R: cd15092 (294 - 319)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

nociceptin receptor

ROR-C

kappa-type 3 opioid receptor

nociceptin receptor ORL1

opiate receptor-like 1

opioid receptor-like 1

orphanin FQ receptor

orphanin FQ receptor-a

orphanin FQ receptor-b

orphanin FQ receptor-e

peptide receptor

seven transmembrane G protein-coupled receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09803 OPRL1 Human Pre-designed siRNA Set A / Unkown
HY-RS09804 Oprl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09805 Oprl1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oprl1 NCBI NCBI:4987