2. Gene
  3. Scn11a - sodium voltage-gated channel alpha subunit 11 Gene

Scn11a - sodium voltage-gated channel alpha subunit 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as NaN

Gene ID: 29701 | Gene type: protein coding

About Scn11a

Primary_assembly 8: 119,496,769-119,567,044 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 96 orthologues, 26 paralogues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 4.9), Spleen (RPKM 4.2) and 3 other tissues.

Summary

Predicted to enable voltage-gated Sodium Channel activity. Predicted to be involved in several processes, including neuronal action potential; regulation of sensory perception of pain; and sodium ion transmembrane transport. Predicted to act upstream of or within sodium ion transport. Located in axon. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). [provided by Alliance of Genome Resources, Apr 2022]

Scn11a Products(1)

mRNA Protein Name
NM_019265.2 NP_062138.1 sodium channel protein type 11 subunit alpha

Scn11a Protein Structure

Ion_trans

Ion_trans: pfam00520 (127 - 403)

Ion_trans

Ion_trans: pfam00520 (570 - 806)

Na_trans_assoc

Na_trans_assoc: pfam06512 (810 - 1028)

Ion_trans

Ion_trans: pfam00520 (1032 - 1296)

Na_channel_gate

Na_channel_gate: cd13433 (1288 - 1340)

Ion_trans

Ion_trans: pfam00520 (1344 - 1594)

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  • 1765 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 11 subunit alpha

sensory neuron sodium channel 2

sodium channel protein type XI subunit alpha

sodium channel, voltage-gated, type 11, alpha polypeptide

sodium channel, voltage-gated, type XI, alpha polypeptide

sodium channel, voltage-gated, type XI, alpha subunit

sodium channel, voltage-gated, type11, alpha polypeptide

voltage-gated sodium channel NAV1.9b

voltage-gated sodium channel subunit alpha Nav1.9

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12522 SCN11A Human Pre-designed siRNA Set A / Unkown
HY-RS12523 Scn11a Mouse Pre-designed siRNA Set A / Unkown
HY-RS12524 Scn11a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn11a NCBI NCBI:11280