Scn11a - sodium voltage-gated channel alpha subunit 11 Gene

Also Known as NaN

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29701

About Scn11a

Primary_assembly 8: 119,496,769-119,567,044 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 96 orthologues, 26 paralogues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 4.9), Spleen (RPKM 4.2) and 3 other tissues.

Summary

Predicted to enable voltage-gated Sodium Channel activity. Predicted to be involved in several processes, including neuronal action potential; regulation of sensory perception of pain; and sodium ion transmembrane transport. Predicted to act upstream of or within sodium ion transport. Located in axon. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). [provided by Alliance of Genome Resources, Apr 2022]

Scn11a Products (1)

mRNA Protein Name
NM_019265.2 NP_062138.1 sodium channel protein type 11 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11376006 RGD
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
10196578 RGD
Biological Process GO Annotation Evidence References Source
involved in membrane depolarization during action potential IDA
IDA: Inferred from direct assay
10196578 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21118538 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19162133 RGD
is active in plasma membrane IDA
IDA: Inferred from direct assay
10196578 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19162133 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn11a Protein Structure

Ion_trans

Ion_trans: pfam00520 (127 - 403)

Ion_trans

Ion_trans: pfam00520 (570 - 806)

Na_trans_assoc

Na_trans_assoc: pfam06512 (810 - 1028)

Ion_trans

Ion_trans: pfam00520 (1032 - 1296)

Na_channel_gate

Na_channel_gate: cd13433 (1288 - 1340)

Ion_trans

Ion_trans: pfam00520 (1344 - 1594)

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  • 1765 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 11 subunit alpha

  • sensory neuron sodium channel 2

  • sodium channel protein type XI subunit alpha

  • sodium channel, voltage-gated, type 11, alpha polypeptide

  • sodium channel, voltage-gated, type XI, alpha polypeptide

  • sodium channel, voltage-gated, type XI, alpha subunit

  • sodium channel, voltage-gated, type11, alpha polypeptide

  • voltage-gated sodium channel NAV1.9b

  • voltage-gated sodium channel subunit alpha Nav1.9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12522 SCN11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12523 Scn11a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12524 Scn11a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990502 Anti-SCN11a/Nav1.9 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn11a NCBI NCBI:11280