2. Gene
  3. ADAM17 - ADAM metallopeptidase domain 17 Gene

ADAM17 - ADAM metallopeptidase domain 17 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 475662 | Gene type: protein coding

About ADAM17

Primary_assembly 17: 6,687,697-6,737,197 reverse strand.ROS_Cfam_1.0:CM025116.1

This gene has 4 transcripts (splice variants), 282 orthologues and 32 paralogues.

ADAM17 Products(6)

mRNA Protein Name
NM_001286867.2 NP_001273796.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 2
NM_001286866.2 NP_001273795.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 1 precursor
NM_001286868.2 NP_001273797.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 3
NM_001286866.2 NP_001273795.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 1 precursor
NM_001286867.2 NP_001273796.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 2
NM_001286868.2 NP_001273797.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 3

ADAM17 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: cl03265 (45 - 162)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (218 - 472)

DISIN

DISIN: smart00050 (479 - 555)

ADAM17_MPD

ADAM17_MPD: pfam16698 (576 - 637)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)

TNF-alpha converting enzyme

a disintegrin and metalloproteinase domain 17

snake venom-like protease

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10293 Aderbasib Inhibitor 99.44% Phase 2
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115670 GW280264X Inhibitor 99.30% Unkown
HY-16657 TAPI-1 Inhibitor 99.36% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-120852 JG26 Inhibitor 98.14% Unkown
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.54% Unkown
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 Substrate 99.33% Unkown
HY-175876 ADAM17-IN-1 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P992406 MEDI-3622 Inhibitor / Unkown
HY-P992341 D8P1C1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ADAM17 NCBI NCBI:6868
Mus musculus ADAM17 NCBI NCBI:11491
Rattus norvegicus ADAM17 NCBI NCBI:57027