PLK4 - polo like kinase 4 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 476087

About PLK4

Primary_assembly 19: 13,131,770-13,150,336 reverse strand.ROS_Cfam_1.0:CM025118.1

This gene has 2 transcripts (splice variants), 209 orthologues and 4 paralogues.

PLK4 Products (2)

mRNA Protein Name
XM_038425796.1 XP_038281724.1 serine/threonine-protein kinase PLK4 isoform X1
XM_038425797.1 XP_038281725.1 serine/threonine-protein kinase PLK4 isoform X2

PLK4 Protein Structure

STKc_PLK4

STKc_PLK4: cd14186 (9 - 264)

Plk4_PB1

Plk4_PB1: pfam18190 (589 - 695)

Plk4_PB2

Plk4_PB2: pfam18409 (697 - 805)

POLO_box_Plk4_3

POLO_box_Plk4_3: cd13116 (882 - 961)

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  • 800
  • 969 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12300 Ocifisertib Inhibitor 99.78% Phase 2
HY-12300B Ocifisertib fumarate Inhibitor 98.69% Phase 2
HY-172737 RP-1664 Inhibitor 98.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18682 Centrinone Inhibitor 98.28% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-18683 Centrinone-B Inhibitor 98.65% Unkown
HY-128493 PLK4-IN-4 Inhibitor 99.89% Unkown
HY-132135 (1E)-CFI-400437 dihydrochloride Inhibitor 98.08% Unkown
HY-149912 CZS-241 Inhibitor / Unkown
HY-12300A Ocifisertib hydrochloride Inhibitor 98.29% Unkown
HY-176734 CZL-S092 Inhibitor / Unkown
HY-134775A PLK4-IN-3 Inhibitor / Unkown
HY-179149 PLK4-IN-6 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-180111 PLK4-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PLK4 NCBI NCBI:10733