EPDR1 - ependymin related 1 Gene

Also Known as EPDR; UCC1; MERP1; MERP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54749

About EPDR1

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:37,920,640-37,951,936 (from NCBI)

This gene has 3 transcripts (splice variants) and 489 orthologues. Broad expression in brain (RPKM 25.1), endometrium (RPKM 24.9) and 23 other tissues.

Summary

The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]

EPDR1 Products (3)

mRNA Protein Name
NM_001242946.2 NP_001229875.2 mammalian ependymin-related protein 1 isoform 2 precursor
NM_001242948.2 NP_001229877.1 mammalian ependymin-related protein 1 isoform 3
NM_017549.5 NP_060019.2 mammalian ependymin-related protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ganglioside GM1 binding IDA
IDA: Inferred from direct assay
30729188 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
30729188 GOA
enables phospholipid binding IPI
IPI: Inferred from physical interaction
30729188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in myofibroblast contraction IMP
IMP: Inferred from mutant phenotype
27245865 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
30729188 GOA
located in lysosome IDA
IDA: Inferred from direct assay
30729188 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPDR1 Protein Structure

Ependymin

Ependymin: Ependymin (81 - 210)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

mammalian ependymin-related protein 1

  • ependymin related protein 1

EPDR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EPDR1 Q9UM22 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
EPDR1 Q9UM22 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
EPDR1 Q9UM22 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
32296183
Intra
EPDR1 Q9UM22 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
EPDR1 Q9UM22 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 PM20D2 Homo sapiens Q8IYS1
Y2H Array
32296183
Intra
EPDR1 Q9UM22 PM20D2 Homo sapiens Q8IYS1
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
EPDR1 Q9UM22 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
EPDR1 Q9UM22 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
EPDR1 Q9UM22 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 EHMT2 Homo sapiens Q96KQ7
Y2H Array
32296183
Intra
EPDR1 Q9UM22 EHMT2 Homo sapiens Q96KQ7
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 IGFBP6 Homo sapiens P24592
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 IGFBP6 Homo sapiens P24592
Y2H Array
32296183
Intra
EPDR1 Q9UM22 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
EPDR1 Q9UM22 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
EPDR1 Q9UM22 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra
EPDR1 Q9UM22 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPDR1 Proteins

Cat. No. Product Name Accession Purity
HY-P70935 EPDR1 Protein, Human (HEK293, His) Q9UM22-1 (A38-S223) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Primary Angle-Closure Glaucoma

  • Primary Angle Closure Glaucoma

  • Angle Closure Glaucoma

  • Acg - [Angle Closure Glaucoma]

  • Angle-Closure Glaucoma

  • Closed Angle Glaucoma

  • Acute Glaucoma

  • Prodromal Angle Closure Glaucoma
Eastern Equine Encephalitis

  • Eee

  • Neuroinvasive Eastern Equine Encephalitis Virus Infection

  • Eastern Equine Encephalomyelitis

  • Encephalomyelitis, Eastern Equine

  • Triple E

  • Eastern Equine Encephalitis Virus Infection

  • Neuroinvasive Eastern Equine Encephalitis Virus Disease

  • Eee - [Eastern Equine Encephalitis]
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04421 EPDR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19432 Epdr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25923 Epdr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EPDR1 MGD MGI:2145369
Bos taurus EPDR1 VGNC VGNC:28530
Canis familiaris EPDR1 VGNC VGNC:51868
Macaca mulatta EPDR1 VGNC VGNC:108399
Rattus norvegicus EPDR1 RGD RGD:1359161
Others EPDR1 NCBI