Ift20 - intraflagellar transport 20 Gene

Mus musculus

Also known as mIFT20; 0610009H04Rik

Gene ID: 55978 | Gene type: protein coding

About Ift20

Summary

Enables opsin binding activity. Involved in several processes, including protein localization to ciliary membrane; regulation of organelle assembly; and regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within several processes, including animal organ development; morphogenesis of a polarized epithelium; and plasma membrane bounded cell projection organization. Located in several cellular components, including ciliary base; microtubule organizing center; and non-motile cilium. Part of intraciliary transport particle B. Orthologous to human IFT20 (intraflagellar transport 20). [provided by Alliance of Genome Resources, Apr 2022]

Ift20 Products(2)

mRNA	Protein	Name
NM_018854.5	NP_061342.1	intraflagellar transport protein 20 homolog
NM_018854.5	NP_061342.1	intraflagellar transport protein 20 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables opsin binding	IPI IPI: Inferred from physical interaction	21307337	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12821668	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	19654211	MGI
acts upstream of or within centrosome localization	IMP IMP: Inferred from mutant phenotype	18981227	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	18981227	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	25605782	MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	25605782	MGI
acts upstream of or within establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	25605782	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	25605782	MGI
acts upstream of or within intraciliary transport	IMP IMP: Inferred from mutant phenotype	24619649	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	18981227	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	21734285	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	21734285	MGI
acts upstream of or within opsin transport	IMP IMP: Inferred from mutant phenotype	21307337	MGI
acts upstream of or within photoreceptor cell outer segment organization	IMP IMP: Inferred from mutant phenotype	21307337	MGI
acts upstream of or within protein localization to cilium	IMP IMP: Inferred from mutant phenotype	21307337	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25605782	MGI
acts upstream of or within protein transmembrane transport	IMP IMP: Inferred from mutant phenotype	28576874	MGI
involved in regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	24089209	MGI
acts upstream of or within regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18981227	MGI
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	24089209	MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway	IMP IMP: Inferred from mutant phenotype	29237719	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19654211	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	31816150	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	27682589	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	21734285	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16775004	MGI
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	31816150	MGI
located in centriole	IDA IDA: Inferred from direct assay	15337773	MGI
located in centrosome	IDA IDA: Inferred from direct assay	19253336	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	22031837	MGI
located in ciliary base	IDA IDA: Inferred from direct assay	15337773	MGI
located in cilium	IDA IDA: Inferred from direct assay	16775004	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	29690537	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	31816150	MGI
located in dendrite terminus	IDA IDA: Inferred from direct assay	20368623	MGI
part of intraciliary transport particle B	IDA IDA: Inferred from direct assay	12821668	MGI
located in kinociliary basal body	IDA IDA: Inferred from direct assay	25605782	MGI
located in manchette	IDA IDA: Inferred from direct assay	29690537	MGI
located in microvillus	IDA IDA: Inferred from direct assay	25605782	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	15337773	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	25605782	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	21307337	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	21307337	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	25605782	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intraflagellar transport protein 20 homolog

intraflagellar transport 20 homolog

uterine protein

Ift20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ift20	Q61025	Atg16l1	Mus musculus	Q8C0J2	Anti Bait CoIP	24089209

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11329	GFP11		98.57%	Unkown
HY-RS06601	IFT20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ift20	NCBI	NCBI:90410

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