Atg16l1 - autophagy related 16-like 1 (S. cerevisiae) Gene

Also Known as WDR30; Apg16l; Atg16l; 1500009K01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77040

Summary

Enables identical protein binding activity. Involved in positive regulation of Autophagy. Acts upstream of or within macroautophagy and negative stranded viral RNA replication. Located in autophagosome membrane and axoneme. Is expressed in central nervous system and retina. Used to study inflammatory bowel disease 10. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to human ATG16L1 (Autophagy related 16 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Atg16l1 Products (3)

mRNA Protein Name
NM_001205391.1 NP_001192320.1 autophagy-related protein 16-1 isoform 1
NM_001205392.1 NP_001192321.1 autophagy-related protein 16-1 isoform 3
NM_029846.4 NP_084122.2 autophagy-related protein 16-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12665549 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12665549 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
11266458 MGI
involved in axonal transport IDA
IDA: Inferred from direct assay
32210230 MGI
involved in axonal transport IEP
IEP: Inferred from expression pattern
32210230 MGI
involved in axonal transport IMP
IMP: Inferred from mutant phenotype
32210230 MGI
acts upstream of or within corpus callosum development IMP
IMP: Inferred from mutant phenotype
29078390 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
33586810 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
29078390 MGI
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
11266458 MGI
involved in microautophagy IMP
IMP: Inferred from mutant phenotype
33586810 MGI
acts upstream of or within negative stranded viral RNA replication IMP
IMP: Inferred from mutant phenotype
24550300 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
30208760 MGI
acts upstream of or within protein lipidation involved in autophagosome assembly IDA
IDA: Inferred from direct assay
24954904 MGI
acts upstream of or within protein localization to phagophore assembly site IPI
IPI: Inferred from physical interaction
24954904 MGI
acts upstream of or within xenophagy IPI
IPI: Inferred from physical interaction
24954904 MGI
Cellular Component GO Annotation Evidence References Source
part of Atg12-Atg5-Atg16 complex IDA
IDA: Inferred from direct assay
12665549 MGI
located in autophagosome IDA
IDA: Inferred from direct assay
12665549 MGI
located in autophagosome membrane IDA
IDA: Inferred from direct assay
21220506 MGI
located in axoneme IDA
IDA: Inferred from direct assay
24089209 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
33087875 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
32210230 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
32210230 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
32210230 MGI
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
12665549 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
33087875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

autophagy-related protein 16-1

  • APG16-like 1

  • Atg16L1 gamma

  • autophagy-related 16-like 1 gamma

Atg16l1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Atg16l1 Q8C0J2 Atg5 Mus musculus Q99J83
Y2H
12665549
Intra
Atg16l1 Q8C0J2 Atg5 Mus musculus Q99J83
Confocal
12665549
Intra
Atg16l1 Q8C0J2 Rb1cc1 Mus musculus Q9ESK9
Crosslink
23392225
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100008 Peretinoin 99.79% Unkown

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-170998 ATG16L1 stabilizer-1 Inducer / Unkown
HY-183730 4E1RCat 17d Inhibitor / Unkown
HY-183731 ATG5 PPI-IN-1 / Unkown
HY-183737 ATG5/TECAIR-IN-1 Inhibitor / Unkown
HY-183738 4E1RCat 27d / Unkown
HY-183807 T1742 Inhibitor / Unkown
HY-183826 ATG5 PPI-IN-4 Inhibitor / Unkown
HY-183827 ATG5 PPI-IN-5 Inhibitor / Unkown
HY-183829 ATG5/TECAIR-IN-3 Inducer / Unkown
HY-183833 Autophagy-IN-9 Inhibitor / Unkown
HY-183835 Autophagy-IN-10 Inhibitor / Unkown
HY-183838 Autophagy-IN-11 Inhibitor / Unkown
HY-183848 ATG5/TECAIR-IN-4 Inhibitor / Unkown
HY-183867 ATG5 PPI-IN-6 Inhibitor / Unkown
HY-RS01143 ATG16L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183732 ATG5 PPI-IN-2 Inhibitor / Unkown
HY-183736 Autophagy-IN-12 Inhibitor / Unkown
HY-183828 ATG5/TECAIR-IN-2 Inhibitor / Unkown
HY-RS19832 Atg16l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26329 Atg16l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg16l1 NCBI NCBI:55054