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Atg5 - autophagy related 5 Gene

Also Known as Apg5l; Atg5l; Paddy; 2010107M05Rik; 3110067M24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11793

Summary

The protein encoded by this gene, in combination with Autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate Antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and Apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Atg5 Products (3)

mRNA	Protein	Name
NM_001314013.1	NP_001300942.1	autophagy protein 5 isoform 2
NM_001358596.1	NP_001345525.1	autophagy protein 5 isoform 3
NM_053069.6	NP_444299.1	autophagy protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11266458	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in aggrephagy	IMP IMP: Inferred from mutant phenotype	22982048	MGI
acts upstream of or within antigen processing and presentation of endogenous antigen	IGI IGI: Inferred from genetic interaction	23382543	MGI
acts upstream of or within antigen processing and presentation of endogenous antigen	IMP IMP: Inferred from mutant phenotype	23382543	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23704209	MGI
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	11266458	MGI
involved in autophagy	IMP IMP: Inferred from mutant phenotype	11266458	MGI
involved in axonal transport	IDA IDA: Inferred from direct assay	32210230	MGI
involved in axonal transport	IEP IEP: Inferred from expression pattern	32210230	MGI
involved in axonal transport	IMP IMP: Inferred from mutant phenotype	32210230	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17450150	MGI
involved in cellular response to nitrosative stress	IMP IMP: Inferred from mutant phenotype	23878245	MGI
acts upstream of or within cellular response to starvation	IMP IMP: Inferred from mutant phenotype	22496425	MGI
acts upstream of positive effect chromatin organization	IMP IMP: Inferred from mutant phenotype	23863932	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within heart contraction	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of or within macroautophagy	IMP IMP: Inferred from mutant phenotype	20453062	MGI
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	11266458	MGI
acts upstream of mucus secretion	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17450150	MGI
involved in negative regulation of defense response to virus	IDA IDA: Inferred from direct assay	17709747	MGI
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	17709747	MGI
acts upstream of or within negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	24035364	MGI
acts upstream of or within negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	17450150	MGI
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	17709747	MGI
acts upstream of or within negative stranded viral RNA replication	IMP IMP: Inferred from mutant phenotype	24550300	MGI
acts upstream of or within negative thymic T cell selection	IGI IGI: Inferred from genetic interaction	23382543	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	23382543	MGI
acts upstream of or within otolith development	IMP IMP: Inferred from mutant phenotype	20577052	MGI
acts upstream of or within positive regulation of mucus secretion	IMP IMP: Inferred from mutant phenotype	24185898	MGI
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	11266458	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	35115539	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	35115539	MGI
acts upstream of or within protein lipidation involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23918802	MGI
acts upstream of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	17450150	MGI
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	24089205	MGI
acts upstream of or within regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	22710871	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	36217825	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	36217825	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within response to fungus	IMP IMP: Inferred from mutant phenotype	22710871	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within ventricular cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	17450150	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Atg12-Atg5-Atg16 complex	IDA IDA: Inferred from direct assay	12665549	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	35115539	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	35115539	MGI
located in autophagosome	IDA IDA: Inferred from direct assay	11266458	MGI
located in axoneme	IDA IDA: Inferred from direct assay	24089209	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11266458	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	32210230	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	32210230	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32210230	MGI
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	23455425	MGI
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	11266458	MGI
part of transferase complex	IDA IDA: Inferred from direct assay	20723759	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
autophagy protein 5

Atg5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Atg5	Q99J83	Atg12	Mus musculus	Q9CQY1	Anti Tag CoIP	12665549
Intra	Atg5	Q99J83	Atg12	Mus musculus	Q9CQY1	Anti Tag CoIP	20723759

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-W018791	Bifendate	99.92%	Unkown
HY-N0538	Xylitol	99.5%	Yes
HY-B0960	Sulfabenzamide	99.68%	Unkown

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N3415	Kumatakenin		99.31%	Unkown
HY-N4120	Valechlorine	Inducer	/	Unkown
HY-RS01152	ATG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23989	Atg5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-151914	Antitumor agent-82	Inducer	/	Unkown
HY-157548	Antitumor agent-133	Inducer	/	Unkown
HY-167843	Alborixin		/	Unkown
HY-170594	Antitumor agent-192	Inducer	/	Unkown
HY-173133	Antitumor agent-199		/	Unkown
HY-179052	Apoptosis inducer 50		/	Unkown
HY-183730	4E1RCat 17d	Inhibitor	/	Unkown
HY-183731	ATG5 PPI-IN-1		/	Unkown
HY-183737	ATG5/TECAIR-IN-1	Inhibitor	/	Unkown
HY-183738	4E1RCat 27d		/	Unkown
HY-183807	T1742	Inhibitor	/	Unkown
HY-183826	ATG5 PPI-IN-4	Inhibitor	/	Unkown
HY-183827	ATG5 PPI-IN-5	Inhibitor	/	Unkown
HY-183829	ATG5/TECAIR-IN-3	Inducer	/	Unkown
HY-183833	Autophagy-IN-9	Inhibitor	/	Unkown
HY-183835	Autophagy-IN-10	Inhibitor	/	Unkown
HY-183838	Autophagy-IN-11	Inhibitor	/	Unkown
HY-183848	ATG5/TECAIR-IN-4	Inhibitor	/	Unkown
HY-183867	ATG5 PPI-IN-6	Inhibitor	/	Unkown
HY-N13352	Bufothionine		/	Unkown
HY-W768347	Xylitol-13C5		/	Unkown
HY-183732	ATG5 PPI-IN-2	Inhibitor	/	Unkown
HY-183736	Autophagy-IN-12	Inhibitor	/	Unkown
HY-183828	ATG5/TECAIR-IN-2	Inhibitor	/	Unkown
HY-RS17532	Atg5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atg5	NCBI	NCBI:9474