Atg12 - autophagy related 12 Gene

Also Known as Apg12l; Atg12l; 4931423H11Rik; A330058M13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67526

Summary

Involved in autophagosome assembly. Located in phagophore assembly site membrane. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human ATG12 (Autophagy related 12). [provided by Alliance of Genome Resources, Apr 2022]

Atg12 Products (1)

mRNA Protein Name
NM_026217.3 NP_080493.2 ubiquitin-like protein ATG12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11266458 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
11266458 MGI
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
11266458 MGI
involved in negative regulation of defense response to virus IDA
IDA: Inferred from direct assay
17709747 MGI
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
17709747 MGI
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
17709747 MGI
Cellular Component GO Annotation Evidence References Source
part of Atg12-Atg5-Atg16 complex IDA
IDA: Inferred from direct assay
12665549 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
20080761 MGI
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
11266458 MGI
part of transferase complex IDA
IDA: Inferred from direct assay
20723759 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like protein ATG12

  • autophagy-related protein 12

Atg12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Atg12 Q9CQY1 Pdcd6ip Mus musculus Q9WU78-1
Anti Bait CoIP
25686249
Intra
Atg12 Q9CQY1 Pdcd6ip Mus musculus Q9WU78-1
Anti Tag CoIP
25686249
Intra
Atg12 Q9CQY1 Atg3 Mus musculus Q9CPX6
Anti Bait CoIP
25686249
Intra
Atg12 Q9CQY1 Atg3 Mus musculus Q9CPX6
Anti Bait CoIP
20723759
Intra
Atg12 Q9CQY1 Atg5 Mus musculus Q99J83
Y2H
12482611
Intra
Atg12 Q9CQY1 Atg5 Mus musculus Q99J83
Biochemical
12482611
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0538 Xylitol 99.5% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156966 ATG12-ATG3 inhibitor 1 Inhibitor 98.19% Unkown
HY-162932 ATG12-IN-1 Inhibitor / Unkown
HY-183826 ATG5 PPI-IN-4 Inhibitor / Unkown
HY-RS01140 ATG12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W768347 Xylitol-13C5 / Unkown
HY-RS21488 Atg12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28006 Atg12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg12 NCBI NCBI:9140