Atg3 - autophagy related 3 Gene

Also Known as APG3; Apg3l; Atg3l; PC3-96; 2610016C12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67841

Summary

Enables Atg12 transferase activity and Atg8 Ligase activity. Involved in autophagosome assembly; mitochondrial fragmentation involved in apoptotic process; and regulation of cilium assembly. Acts upstream of or within macroautophagy and negative regulation of phagocytosis. Predicted to be located in cytoplasm. Predicted to be part of cytoplasmic ubiquitin Ligase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ATG3 (Autophagy related 3). [provided by Alliance of Genome Resources, Apr 2022]

Atg3 Products (2)

mRNA Protein Name
NM_001356366.1 NP_001343295.1 ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_026402.3 NP_080678.1 ubiquitin-like-conjugating enzyme ATG3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Atg12 transferase activity IDA
IDA: Inferred from direct assay
20723759 MGI
enables Atg8-family ligase activity IMP
IMP: Inferred from mutant phenotype
20723759 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18321988 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
24747438 MGI
acts upstream of or within autophagosome assembly IMP
IMP: Inferred from mutant phenotype
21220506 MGI
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
20723759 MGI
involved in autophagy IMP
IMP: Inferred from mutant phenotype
18768753 MGI
acts upstream of or within macroautophagy IMP
IMP: Inferred from mutant phenotype
24035364 MGI
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20723759 MGI
acts upstream of or within negative regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
24035364 MGI
involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
24089205 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like-conjugating enzyme ATG3

  • autophagy-related protein 3

Atg3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Atg3 Q9CPX6 Atg12 Mus musculus Q9CQY1
Anti Tag CoIP
20723759
Intra
Atg3 Q9CPX6 Atg12 Mus musculus Q9CQY1
Anti Tag CoIP
25686249
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156966 ATG12-ATG3 inhibitor 1 Inhibitor 98.19% Unkown
HY-RS01147 ATG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162932 ATG12-IN-1 Inhibitor / Unkown
HY-RS18909 Atg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25400 Atg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg3 NCBI NCBI:64422