ATG3 - autophagy related 3 Gene

Also Known as APG3; APG3L; hApg3; PC3-96; APG3-LIKE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64422

About ATG3

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,532,510-112,561,962 (from NCBI)

This gene has 9 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 24.5), bone marrow (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in Autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of Autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

ATG3 Products (2)

mRNA	Protein	Name
NM_001278712.2	NP_001265641.1	ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_022488.5	NP_071933.2	ubiquitin-like-conjugating enzyme ATG3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables Atg8-family conjugating enzyme activity	IDA IDA: Inferred from direct assay	12207896	GOA
enables Atg8-family conjugating enzyme activity	IMP IMP: Inferred from mutant phenotype	24191030	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11825910	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11825910	GOA
enables ubiquitin-like protein transferase activity	IDA IDA: Inferred from direct assay	11825910	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	33446636	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	11825910	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of Atg12-Atg5-Atg16 complex	IDA IDA: Inferred from direct assay	24186333	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	11825910	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11825910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG3 Protein Structure

Autophagy_N

Autophagy_act_C

Autophagy_C

0
100
200
300
314 a.a.

Protein Preferred Names	Protein Names
ubiquitin-like-conjugating enzyme ATG3	APG3 autophagy 3-like

ATG3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ATG3	Q9NT62	TECPR1	Homo sapiens	Q7Z6L1	Anti Tag CoIP	20562859
Intra	ATG3	Q9NT62	GNB2	Homo sapiens	P62879	Validated Y2H	32814053
Intra	ATG3	Q9NT62	GNB2	Homo sapiens	P62879	Y2H Pooling	32814053
Intra	ATG3	Q9NT62	GNB2	Homo sapiens	P62879	Y2H Array	32814053
Intra	ATG3	Q9NT62	MAP1LC3B	Homo sapiens	Q9GZQ8	Comig Non-Denat Gel	16303767
Intra	ATG3	Q9NT62	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG3	Q9NT62	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	20562859
Intra	ATG3	Q9NT62	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	ATG3	Q9NT62	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	33961781
Intra	ATG3	Q9NT62	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ATG3	Q9NT62	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	35271311
Intra	ATG3	Q9NT62	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	20562859
Intra	ATG3	Q9NT62	GABARAPL2	Homo sapiens	P60520	Comig Non-Denat Gel	16303767
Intra	ATG3	Q9NT62	ATG12	Homo sapiens	O94817	Anti Tag CoIP	20562859
Intra	ATG3	Q9NT62	ATG12	Homo sapiens	O94817	Anti Tag CoIP	33961781
Intra	ATG3	Q9NT62	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATG3 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7617	ATG3 Protein, Human	Q9NT62 (M1-M314)	≥ 95%, as determined by reducing SDS-PAGE.

ATG3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80556	ATG3 Antibody (YA602)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84825	ATG3 Antibody (YA4522)	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
HY-P84825A	ATG3 Antibody (YA4522)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
HY-P84826	ATG3 Antibody (YA4523)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84826A	ATG3 Antibody (YA4523)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P86236	ATG3 Antibody (YA5928)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Granulomatous Amebic Encephalitis	Granulomatous Amoebic Encephalitis Acanthamoeba Encephalitis Acanthamoeba Granulomatous Encephalitis Granulomatous Amebic Encephalitis Due To Acanthamoeba
Primary Amebic Meningoencephalitis	Pam Naegleria Fowleri Infection Meningoencephalitis Caused By Naegleria Fowleri Primary Amoebic Meningoencephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-156966	ATG12-ATG3 inhibitor 1	Inhibitor	98.19%	Unkown
HY-RS01147	ATG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162932	ATG12-IN-1	Inhibitor	/	Unkown
HY-RS18909	Atg3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25400	Atg3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATG3	VGNC	VGNC:103660
Rattus norvegicus	ATG3	RGD	RGD:708464
Mus musculus	ATG3	MGD	MGI:1915091
Bos taurus	ATG3	VGNC	VGNC:26256
Macaca mulatta	ATG3	VGNC	VGNC:70105
Felis catus	ATG3	VGNC	VGNC:102599
Others	ATG3	NCBI