Pth1r - parathyroid hormone 1 receptor Gene

Also Known as Pthr; Pthr1; PTHrel

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56813

Summary

Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Pth1r Products (1)

mRNA Protein Name
NM_020073.2 NP_064458.1 parathyroid hormone/parathyroid hormone-related peptide receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables parathyroid hormone receptor activity IDA
IDA: Inferred from direct assay
1313566 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
9054374 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
IMP: Inferred from mutant phenotype
8662729 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19608645 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19608645 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9054374 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
1313566 RGD
involved in positive regulation of inositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
19608645 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19608645 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12647298 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
12647298 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
19608645 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

parathyroid hormone/parathyroid hormone-related peptide receptor

  • PTH/PTHr receptor

  • PTH/PTHrP type I receptor

  • PTH1 receptor

  • parathyroid hormone receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 99.77% Unkown
HY-P4821 pTH (1-34) amide (human) Agonist 99.78% Unkown
HY-176943 PTH1R agonist 1 Agonist / Unkown
HY-176945 PTH1R agonist 3 Agonist / Unkown
HY-120398 CH5447240 Agonist / Unkown
HY-186200 PTHR1 antagonist 1 Antagonist / Unkown
HY-176944 PTH1R agonist 2 Agonist / Unkown
HY-113918 SW-106 Antagonist / Unkown
HY-131206 DS37571084 Antagonist / Unkown
HY-179356 Octadecyl β-D-glucopyranosiduronic acid Activator / Unkown
HY-176946 PTH1R agonist 4 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pth1r NCBI NCBI:5745