GPR158 - G protein-coupled receptor 158 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57512

About GPR158

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:25,175,001-25,602,229 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 1 paralogue. Biased expression in brain (RPKM 11.3), adrenal (RPKM 0.9) and 1 other tissue.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR158 Products (1)

mRNA Protein Name
NM_020752.3 NP_065803.2 probable G-protein coupled receptor 158 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled glycine receptor activity IDA
IDA: Inferred from direct assay
36996198 GOA
enables enzyme activator activity IDA
IDA: Inferred from direct assay
31189666 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
31189666 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
31189666 GOA
involved in regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
36996198 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
31189666 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR158 Protein Structure

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (427 - 667)

  • 0
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  • 1000
  • 1215 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 158

Related Diseases

Diseases Alias
Smallpox

  • Variola

  • Ordinary Smallpox

  • Alastrim

  • Amaas
Night Blindness, Congenital Stationary, Type 1b

  • Congenital Stationary Night Blindness 1b

  • CSNB1B

  • Night Blindness, Congenital Stationary, Complete, Autosomal Recessive

  • Csnb, Complete, Autosomal Recessive

  • Night Blindness, Congenital Stationary , 1b, Autosomal Recessive

  • Autosomal Recessive Complete Congenital Stationary Night Blindness

  • Congenital Stationary Night Blindness 1b Autosomal Recessive

  • Night Blindness, Congenital Stationary, 1b

  • Complete Autosomal Recessive Csnb

  • Complete Congenital Stationary Night Blindness Autosomal Recessive

  • Blindness, Night, Stationary, Congenital, Type 1b
Cataract 4, Multiple Types

  • Cataract 4 Multiple Types

  • CTRCT4

  • Cca3

  • Pcc

  • Aculeiform Cataract

  • Cataract 4, Multiple Types, With Or Without Microcornea

  • Cataract, Crystalline Aculeiform

  • Caca

  • Cataract, Congenital, Cerulean Type, 3

  • Congenital Cataract Cerulean Type 3

  • Cataract Congenital Dominant Non Nuclear

  • Ccp

  • Cataract, Nonnuclear Polymorphic Congenital

  • Cataract, Punctate, Progressive Juvenile-Onset

  • Cataract 4 Multiple Types With Or Without Microcornea

  • Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

  • Cataract, Polymorphic Congenital

  • Congenital Cataract Blue Dot Type 3

  • Congenital Non-Nuclear Polymorphic Cataract

  • Crystalline Aculeiform Cataract

  • Punctate, Progressive Juvenile-Onset, Cataract

  • Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Congenital Stationary Night Blindness

  • Night Blindness, Congenital Stationary

  • Congenital Essential Nyctalopia

  • Oguchi Disease

  • Blindness, Night, Stationary, Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05675 GPR158 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19507 Gpr158 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26001 Gpr158 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR158 VGNC VGNC:29564
Canis familiaris GPR158 VGNC VGNC:41410
Macaca mulatta GPR158 VGNC VGNC:103821
Rattus norvegicus GPR158 RGD RGD:1305841
Mus musculus GPR158 MGD MGI:2441697
Others GPR158 NCBI