RAC2 - Rac family small GTPase 2 Gene

Also Known as Gx; EN-7; IMD73A; IMD73B; IMD73C; HSPC022; p21-Rac2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5880

About RAC2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,225,270-37,244,269 (from NCBI)

This gene has 8 transcripts (splice variants), 235 orthologues, 22 paralogues and is associated with 4 phenotypes. Biased expression in lymph node (RPKM 157.7), bone marrow (RPKM 130.6) and 9 other tissues.

Summary

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of Reactive Oxygen Species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

RAC2 Products (1)

mRNA	Protein	Name
NM_002872.5	NP_002863.1	ras-related C3 botulinum toxin substrate 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	19625648	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22106281	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	21167572	GOA
involved in lymphocyte aggregation	IMP IMP: Inferred from mutant phenotype	21167572	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	19625648	GOA
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	19625648	GOA
involved in regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	21167572	GOA
involved in regulation of neutrophil migration	IMP IMP: Inferred from mutant phenotype	21167572	GOA
involved in regulation of respiratory burst	IDA IDA: Inferred from direct assay	16636067	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	19625648	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19625648	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	19625648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAC2 Protein Structure

Ras

0
100
192 a.a.

Protein Preferred Names	Protein Names
ras-related C3 botulinum toxin substrate 2	Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)

RAC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAC2	P15153	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	RAC2	P15153	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74607	RAC2 Protein, Human (His)	P15153 (M1-C189)	≥ 95%, as determined by reducing SDS-PAGE.

RAC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87058	Rac1-2-3 Antibody (YA6751)	WB, ICC/IF, IF-Tissue, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis	Neutrophil Immunodeficiency Syndrome IMD73A Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis Rac 2 Deficiency
Immunodeficiency 73b With Defective Neutrophil Chemotaxis And Lymphopenia	IMD73B Immunodeficiency, Type 73b, With Defective Neutrophil Chemotaxis And Lymphopenia
Immunodeficiency 73c With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia	IMD73C
Lymphopenia	Lymphocytopenia
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Combined T And B Cell Immunodeficiency
Cellulitis
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Deafness, Autosomal Recessive 104	DFNB104 Autosomal Recessive Nonsyndromic Deafness 104 Autosomal Recessive Deafness 104 Deafness, Autosomal Recessive, 104 Deafness, Autosomal Recessive, Type 104
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Immunodeficiency 40	Dock2 Deficiency IMD40 Immunodeficiency, Type 40
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Phagocyte Bactericidal Dysfunction	Phagocytic Dysfunction
Whim Syndrome 1	Whim Syndrome Whims Warts, Hypogammaglobulinemia, Infections, And Myelokathexis WHIMS1 Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1 Myelokathexis, Isolated Wilm Warts-Infections-Leukopenia-Myelokatexis Syndrome Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-113849	MLS-573151	Inhibitor	99.66%	Unkown
HY-132316S	(rac)-2,4-O-Dimethylzearalenone-d6		/	Unkown
HY-RS11592	RAC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W051624S	(Rac)-2-Aminothiazoline-4-carboxylic acid-13C,15N2		/	Unkown
HY-W704952	rac 2-(tert-Butyldimethylsilyloxy) Ibuprofen-d6		/	Unkown
HY-W756586	Rac 2-stearoyl-3-chloropropanediol-13C3		/	Unkown
HY-W756589	Rac 2-linolenoyl-3-chloropropanediol-13C3		/	Unkown
HY-143681S	(Rac)-2-Palmitoyl-3-chloropropanediol-d5		/	Unkown
HY-RS17270	Rac2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23724	Rac2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W010590S	(Rac)-2-Aminobutyric acid-d3		/	Unkown
HY-W440982A	(Rac)-SOPC		/	Unkown
HY-W778187	rac 2-Oleoyl-3-chloropropanediol-d5,95%		/	Unkown
HY-W778189	rac-2-Linoleoyl-3-chloropropanediol-d5,95%		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAC2	VGNC	VGNC:98432
Mus musculus	RAC2	MGD	MGI:97846
Felis catus	RAC2	VGNC	VGNC:69209
Rattus norvegicus	RAC2	RGD	RGD:1307568
Canis familiaris	RAC2	VGNC	VGNC:49610
Bos taurus	RAC2	VGNC	VGNC:49061
Others	RAC2	NCBI