Unc5b - unc-5 netrin receptor B Gene

Also Known as Unc5h2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60630

Summary

Enables netrin receptor activity. Involved in axon guidance and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in membrane raft. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Apr 2022]

Unc5b Products (1)

mRNA Protein Name
NM_022207.2 NP_071543.2 netrin receptor UNC5B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables netrin receptor activity IDA
IDA: Inferred from direct assay
9126742 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18469807 RGD
Biological Process GO Annotation Evidence References Source
involved in axon guidance IDA
IDA: Inferred from direct assay
9126742 RGD
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
21673655 RGD
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
21172653 RGD
Cellular Component GO Annotation Evidence References Source
located in membrane raft IDA
IDA: Inferred from direct assay
21172653 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

netrin receptor UNC5B

  • protein unc-5 homolog 2

  • protein unc-5 homolog B

  • transmembrane receptor Unc5H2

  • unc-5 homolog 2

  • unc-5 homolog B

Unc5b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Unc5b O08722 PPP2R1B Homo sapiens P30154
Y2H
21172653
Intra
Unc5b O08722 Agap2 Rattus norvegicus Q8CGU4
Anti Bait CoIP
18469807
Intra
Unc5b O08722 Agap2 Rattus norvegicus Q8CGU4
Confocal
18469807
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Unc5b Proteins

Cat. No. Product Name Accession Purity
HY-P76120 UNC5B Protein, Rat (HEK293, Fc) O08722/NP_071543.1 (G27-D373) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15472 UNC5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18193 Unc5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24667 Unc5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991624 Anti-UNC5B Antibody (YW88) Inhibitor 95.17% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Unc5b NCBI NCBI:219699