Degs2 - delta(4)-desaturase, sphingolipid 2 Gene

Also Known as DES2; 2210008A03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70059

Summary

Enables sphingolipid delta-4 desaturase activity and sphingosine hydroxylase activity. Acts upstream of or within ceramide biosynthetic process and sphinganine metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in stomach. Orthologous to human DEGS2 (delta 4-desaturase, sphingolipid 2). [provided by Alliance of Genome Resources, Apr 2022]

Degs2 Products (2)

mRNA Protein Name
NM_001171002.1 NP_001164473.1 sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform 2
NM_027299.5 NP_081575.2 sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sphingolipid delta-4 desaturase activity IGI
IGI: Inferred from genetic interaction
11937514 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within sphinganine metabolic process IGI
IGI: Inferred from genetic interaction
11937514 MGI
acts upstream of or within sphingolipid biosynthetic process IGI
IGI: Inferred from genetic interaction
11937514 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingolipid delta(4)-desaturase/C4-monooxygenase DES2

  • degenerative spermatocyte homolog 2, lipid desaturase

  • sphingolipid 4-desaturase

  • sphingolipid C4-monooxygenase

  • sphingolipid delta 4 desaturase/C-4 hydroxylase

  • sphingolipid delta(4)-desaturase/C4-hydroxylase DES2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161804 GNF-2-deg Degrader / Unkown
HY-RS03683 DEGS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20908 Degs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27425 Degs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Degs2 NCBI NCBI:123099