Megf10 - multiple EGF-like-domains 10 Gene

Also Known as Gm331; 3000002B06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70417

Summary

Enables Notch binding activity. Involved in several processes, including myoblast migration; skeletal muscle satellite cell differentiation; and skeletal muscle satellite cell proliferation. Acts upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and recognition of apoptotic cell. Located in phagocytic cup. Is expressed in several structures, including cerebellum; dorsal root ganglion; retina layer; skeletal muscle tissue; and testis. Human ortholog(s) of this gene implicated in early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10). [provided by Alliance of Genome Resources, Apr 2022]

Megf10 Products (1)

mRNA Protein Name
NM_001001979.2 NP_001001979.1 multiple epidermal growth factor-like domains protein 10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Notch binding IPI
IPI: Inferred from physical interaction
28498977 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic process involved in development IMP
IMP: Inferred from mutant phenotype
27170117 MGI
acts upstream of or within engulfment of apoptotic cell IMP
IMP: Inferred from mutant phenotype
27170117 MGI
involved in myoblast development IMP
IMP: Inferred from mutant phenotype
31267131 MGI
involved in myoblast migration IMP
IMP: Inferred from mutant phenotype
28498977 MGI
involved in positive regulation of myoblast proliferation IMP
IMP: Inferred from mutant phenotype
31267131 MGI
acts upstream of or within recognition of apoptotic cell IDA
IDA: Inferred from direct assay
19915564 MGI
acts upstream of or within recognition of apoptotic cell IMP
IMP: Inferred from mutant phenotype
19915564 MGI
involved in skeletal muscle satellite cell activation IMP
IMP: Inferred from mutant phenotype
18056409 MGI
involved in skeletal muscle satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
18056409 MGI
involved in skeletal muscle satellite cell proliferation IDA
IDA: Inferred from direct assay
18056409 MGI
Cellular Component GO Annotation Evidence References Source
located in phagocytic cup IDA
IDA: Inferred from direct assay
19915564 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17643423 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

multiple epidermal growth factor-like domains protein 10

  • multiple EGF-like domains protein 10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18007 Megf10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08314 MEGF10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24480 Megf10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Megf10 NCBI NCBI:84466