Atp6ap2 - ATPase, H+ transporting, lysosomal accessory protein 2 Gene

Also Known as PRR; M8-9; (P)RR; Atp6ip2; APT6M8-9; ATP6M8-9; 5730403E06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70495

Summary

Predicted to enable signaling receptor activity. Involved in central nervous system maturation and positive regulation of Wnt signaling pathway. Located in endosome membrane and lysosomal membrane. Is expressed in several structures, including decidua; extraembryonic component; forebrain; neural retina; and renal cortex. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp6ap2 Products (1)

mRNA Protein Name
NM_027439.4 NP_081715.1 renin receptor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in central nervous system maturation IMP
IMP: Inferred from mutant phenotype
30985297 MGI
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20093472 MGI
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome membrane IDA
IDA: Inferred from direct assay
30985297 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
30985297 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

renin receptor

  • ATPase H(+)-transporting lysosomal-interacting protein 2

  • ATPase, H+ transporting, lysosomal interacting protein 1

  • ATPase, H+ transporting, lysosomal interacting protein 2

  • prorenin receptor

  • renin/prorenin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01215 ATP6AP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19275 Atp6ap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25764 Atp6ap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6ap2 NCBI NCBI:10159