2. Gene
  3. Mir223 - microRNA 223 Gene

Mir223 - microRNA 223 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn223; miR-223; mmu-mir-223

Gene ID: 723814 | Gene type: ncRNA

About Mir223

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of cell proliferation in bone marrow IMP
IMP: Inferred from mutant phenotype
18278031 MGI
acts upstream of or within cellular response to decreased oxygen levels IEP
IEP: Inferred from expression pattern
19147652 MGI
acts upstream of or within cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18791161 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
18762567 MGI
acts upstream of granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
18278031 MGI
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IMP
IMP: Inferred from mutant phenotype
18278031 MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow IMP
IMP: Inferred from mutant phenotype
18278031 MGI
acts upstream of or within positive regulation of granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
18278031 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
18791161 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18791161 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
18723672 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W176171 PU.1-IN-1 Inhibitor 99.72% Unkown
HY-R00467 hsa-miR-223-3p mimic 98.07% Unkown
HY-R00467A hsa-miR-223-3p agomir 97.24% Unkown
HY-RI00467 hsa-miR-223-3p inhibitor 98.66% Unkown
HY-RI00467A hsa-miR-223-3p antagomir 95.82% Unkown
HY-R00468 hsa-miR-223-5p mimic / Unkown
HY-R00468A hsa-miR-223-5p agomir / Unkown
HY-R02848 mmu-miR-223-5p mimic / Unkown
HY-R02848A mmu-miR-223-5p agomir / Unkown
HY-R04313 rno-miR-223-3p mimic / Unkown
HY-R04313A rno-miR-223-3p agomir / Unkown
HY-RI00468 hsa-miR-223-5p inhibitor / Unkown
HY-RI00468A hsa-miR-223-5p antagomir / Unkown
HY-RI02848 mmu-miR-223-5p inhibitor / Unkown
HY-RI02848A mmu-miR-223-5p antagomir / Unkown
HY-RI04313 rno-miR-223-3p inhibitor / Unkown
HY-RI04313A rno-miR-223-3p antagomir 99.03% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir223 NCBI NCBI:407008