Scn9a - sodium voltage-gated channel alpha subunit 9 Gene

Rattus norvegicus

Also known as PN1; Scn2a; Nav1.7

Gene ID: 78956 | Gene type: protein coding

About Scn9a

Primary_assembly 3: 51,145,146-51,293,516 reverse strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 111 orthologues, 26 paralogues and is associated with 44 phenotypes. Biased expression in Brain (RPKM 67.9), Adrenal (RPKM 18.) and 3 other tissues.

Summary

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in several processes, including behavioral response to formalin induced pain; negative regulation of action potential; and neuronal action potential. Located in axon. Part of voltage-gated Sodium Channel complex. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]

Scn9a Products(1)

mRNA	Protein	Name
NM_133289.2	NP_579823.1	sodium channel protein type 9 subunit alpha

Scn9a Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

0
400
800
1200
1600
1984 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 9 subunit alpha

peripheral sodium channel 1	sodium channel protein type IX subunit alpha
sodium channel, voltage-gated, type 9, alpha polypeptide	sodium channel, voltage-gated, type IX, alpha subunit
voltage-gated sodium channel subunit alpha Nav1.7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12548	SCN9A Human Pre-designed siRNA Set A	/	Unkown
HY-RS12549	Scn9a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS12550	Scn9a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn9a	NCBI	NCBI:6335

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