Kiss1r - KISS1 receptor Gene

Also Known as Gpr54

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78976

About Kiss1r

Primary_assembly 7: 9,785,135-9,788,793 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 135 orthologues, 14 paralogues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 5.8), Testes (RPKM .9) and 1 other tissue.

Summary

Enables G protein-coupled peptide receptor activity and neuropeptide binding activity. Involved in several processes, including arachidonic acid secretion; positive regulation of cell communication; and positive regulation of stress fiber assembly. Located in membrane. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Kiss1r Products (2)

mRNA Protein Name
NM_001301151.1 NP_001288080.1 kiSS-1 receptor isoform 2
NM_023992.2 NP_076482.2 kiSS-1 receptor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IPI
IPI: Inferred from physical interaction
11457843 RGD
enables neuropeptide binding IDA
IDA: Inferred from direct assay
11414709 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16222076 RGD
involved in arachidonate secretion IDA
IDA: Inferred from direct assay
11457843 RGD
involved in calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
16222076 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11457843 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
11457843 RGD
involved in positive regulation of hormone secretion IDA
IDA: Inferred from direct assay
11457843 RGD
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
11457843 RGD
involved in positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
16222076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kiss1r Protein Structure

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (42 - 333)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (43 - 69)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (76 - 102)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (114 - 144)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (156 - 176)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (200 - 229)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (255 - 285)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (301 - 326)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

kiSS-1 receptor

  • G protein-coupled receptor 54

  • G-protein coupled receptor OT7T175

  • kiSS-

  • kiSS-1R

  • kisspeptins receptor

  • metastin receptor

  • orphan G protein-coupled receptor GPR54

  • rOT7T175

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P0076 TAK-448 99.90% Phase 2
HY-P0076A TAK-448 acetate 99.79% Phase 2
HY-P2161 TAK-683 / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10489 Kisspeptin-14 human 99.70% Unkown
HY-P2161B TAK-683 acetate 99.91% Unkown
HY-RS07316 KISS1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P2161A TAK-683 TFA / Unkown
HY-P2191 KISS1-305 / Unkown
HY-RS07317 Kiss1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07318 Kiss1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kiss1r NCBI NCBI:84634