ST8SIA4 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Gene

Also Known as PST; PST1; SIAT8D; ST8SIA-IV

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7903

About ST8SIA4

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:100,806,933-100,903,282 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 5 paralogues. Broad expression in appendix (RPKM 6.6), lymph node (RPKM 4.8) and 19 other tissues.

Summary

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of Glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ST8SIA4 Products (2)

mRNA Protein Name
NM_005668.6 NP_005659.1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor
NM_175052.3 NP_778222.1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
IDA: Inferred from direct assay
9774483 GOA
enables sialyltransferase activity IDA
IDA: Inferred from direct assay
28810663 GOA
Biological Process GO Annotation Evidence References Source
involved in N-glycan processing IDA
IDA: Inferred from direct assay
10766765 GOA
involved in ganglioside biosynthetic process IDA
IDA: Inferred from direct assay
10766765 GOA
involved in oligosaccharide metabolic process IDA
IDA: Inferred from direct assay
10766765 GOA
involved in protein glycosylation IDA
IDA: Inferred from direct assay
10766765 GOA
involved in sialylation IDA
IDA: Inferred from direct assay
7624364 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
9852130 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST8SIA4 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (92 - 355)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

  • CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase

Related Diseases

Diseases Alias
Dystonia 16

  • DYT16

  • Dyt-Prkra

  • Dystonia-16

  • Young-Onset Dystonia-

  • Early-Onset Dystonia Parkinsonism

  • Dystonia, Type 16
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70301 ST8 alpha-2,8-Sialyltransferase 4 / Unkown
HY-RS13858 ST8SIA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ST8SIA4 RGD RGD:621845
Bos taurus ST8SIA4 VGNC VGNC:35346
Felis catus ST8SIA4 VGNC VGNC:65737
Macaca mulatta ST8SIA4 VGNC VGNC:77832
Mus musculus ST8SIA4 MGD MGI:106018
Canis familiaris ST8SIA4 VGNC VGNC:46866
Others ST8SIA4 NCBI