2. Gene
  3. ST8SIA4 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Gene

ST8SIA4 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PST; PST1; SIAT8D; ST8SIA-IV

Gene ID: 7903 | Gene type: protein coding

About ST8SIA4

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:100,806,933-100,903,282 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 5 paralogues. Broad expression in appendix (RPKM 6.6), lymph node (RPKM 4.8) and 19 other tissues.

Summary

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ST8SIA4 Products(2)

mRNA Protein Name
NM_005668.6 NP_005659.1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor
NM_175052.3 NP_778222.1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform b precursor

ST8SIA4 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (92 - 355)

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  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase

Related Diseases

Diseases Alias
Dystonia 16

DYT16

Dyt-Prkra

Dystonia-16

Young-Onset Dystonia-

Early-Onset Dystonia Parkinsonism

Dystonia, Type 16
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70301 ST8 alpha-2,8-Sialyltransferase 4 / Unkown
HY-RS13858 ST8SIA4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ST8SIA4 RGD RGD:621845
Bos taurus ST8SIA4 VGNC VGNC:35346
Felis catus ST8SIA4 VGNC VGNC:65737
Macaca mulatta ST8SIA4 VGNC VGNC:77832
Mus musculus ST8SIA4 MGD MGI:106018
Canis familiaris ST8SIA4 VGNC VGNC:46866