SVEP1 - sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Gene

Homo sapiens

Also known as CCP22; SELOB; SEL-OB; C9orf13; POLYDOM

Gene ID: 79987 | Gene type: protein coding

About SVEP1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:110,365,248-110,579,741 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 39 paralogues. Biased expression in placenta (RPKM 31.0), fat (RPKM 15.2) and 13 other tissues.

Summary

Predicted to enable calcium ion binding activity and chromatin binding activity. Predicted to be involved in epidermis development and lymph vessel morphogenesis. Predicted to act upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SVEP1 Products(1)

mRNA	Protein	Name
NM_153366.4	NP_699197.3	sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor

SVEP1 Protein Structure

VWA

Ephrin_rec_like

Sushi

HYR

Ephrin_rec_like

EGF

Pentaxin

Sushi

EGF_CA

Sushi

hEGF

0
600
1200
1800
2400
3000
3548 a.a.

Protein Preferred Names

Protein Names

sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

CCP module-containing protein 22

Related Diseases

Diseases

Alias

Autosomal Dominant Nonsyndromic Deafness 78

Dfna78

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14058	SVEP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SVEP1	RGD	RGD:1588987
Canis familiaris	SVEP1	VGNC	VGNC:47006
Felis catus	SVEP1	VGNC	VGNC:65863
Mus musculus	SVEP1	MGD	MGI:1928849
Bos taurus	SVEP1	VGNC	VGNC:56985

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