SVEP1 - sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Gene

Also Known as CCP22; SELOB; SEL-OB; C9orf13; POLYDOM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79987

About SVEP1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:110,365,248-110,579,741 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 39 paralogues. Biased expression in placenta (RPKM 31.0), fat (RPKM 15.2) and 13 other tissues.

Summary

Predicted to enable calcium ion binding activity and chromatin binding activity. Predicted to be involved in epidermis development and lymph vessel morphogenesis. Predicted to act upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SVEP1 Products (1)

mRNA Protein Name
NM_153366.4 NP_699197.3 sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
35802072 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
35802072 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
35802072 GOA
involved in positive regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
36792666 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27892606 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27892606 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SVEP1 Protein Structure

VWA

VWA: von Willebrand factor type A domain (61 - 229)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (287 - 337)

Sushi

Sushi: Sushi repeat (SCR repeat) (355 - 407)

Sushi

Sushi: Sushi repeat (SCR repeat) (415 - 470)

HYR

HYR: HYR domain (538 - 619)

HYR

HYR: HYR domain (621 - 698)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (982 - 1029)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (1036 - 1083)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (1090 - 1137)

EGF

EGF: EGF-like domain (1174 - 1203)

EGF

EGF: EGF-like domain (1212 - 1242)

EGF

EGF: EGF-like domain (1250 - 1280)

EGF

EGF: EGF-like domain (1326 - 1356)

EGF

EGF: EGF-like domain (1364 - 1394)

Pentaxin

Pentaxin: Pentaxin family (1419 - 1597)

Sushi

Sushi: Sushi repeat (SCR repeat) (1605 - 1662)

Sushi

Sushi: Sushi repeat (SCR repeat) (1667 - 1720)

EGF_CA

EGF_CA: Calcium-binding EGF domain (1722 - 1760)

Sushi

Sushi: Sushi repeat (SCR repeat) (1766 - 1819)

Sushi

Sushi: Sushi repeat (SCR repeat) (1824 - 1877)

Sushi

Sushi: Sushi repeat (SCR repeat) (1882 - 1935)

Sushi

Sushi: Sushi repeat (SCR repeat) (1940 - 1993)

Sushi

Sushi: Sushi repeat (SCR repeat) (1998 - 2055)

Sushi

Sushi: Sushi repeat (SCR repeat) (2060 - 2113)

Sushi

Sushi: Sushi repeat (SCR repeat) (2123 - 2176)

Sushi

Sushi: Sushi repeat (SCR repeat) (2181 - 2236)

Sushi

Sushi: Sushi repeat (SCR repeat) (2241 - 2295)

Sushi

Sushi: Sushi repeat (SCR repeat) (2300 - 2353)

Sushi

Sushi: Sushi repeat (SCR repeat) (2358 - 2412)

Sushi

Sushi: Sushi repeat (SCR repeat) (2417 - 2470)

Sushi

Sushi: Sushi repeat (SCR repeat) (2475 - 2528)

Sushi

Sushi: Sushi repeat (SCR repeat) (2533 - 2585)

Sushi

Sushi: Sushi repeat (SCR repeat) (2644 - 2689)

Sushi

Sushi: Sushi repeat (SCR repeat) (2694 - 2747)

Sushi

Sushi: Sushi repeat (SCR repeat) (2752 - 2805)

Sushi

Sushi: Sushi repeat (SCR repeat) (2810 - 2863)

Sushi

Sushi: Sushi repeat (SCR repeat) (2868 - 2921)

Sushi

Sushi: Sushi repeat (SCR repeat) (2926 - 2979)

Sushi

Sushi: Sushi repeat (SCR repeat) (2984 - 3036)

Sushi

Sushi: Sushi repeat (SCR repeat) (3061 - 3094)

Sushi

Sushi: Sushi repeat (SCR repeat) (3099 - 3149)

Sushi

Sushi: Sushi repeat (SCR repeat) (3158 - 3213)

Sushi

Sushi: Sushi repeat (SCR repeat) (3218 - 3267)

Sushi

Sushi: Sushi repeat (SCR repeat) (3276 - 3329)

Sushi

Sushi: Sushi repeat (SCR repeat) (3334 - 3388)

Sushi

Sushi: Sushi repeat (SCR repeat) (3393 - 3445)

hEGF

hEGF: Human growth factor-like EGF (3496 - 3508)

  • 0
  • 600
  • 1200
  • 1800
  • 2400
  • 3000
  • 3548 a.a.
Protein Preferred Names Protein Names

sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

  • CCP module-containing protein 22

Related Diseases

Diseases Alias
Autosomal Dominant Nonsyndromic Deafness 78

  • Dfna78
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14058 SVEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21775 Svep1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28292 Svep1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SVEP1 RGD RGD:1588987
Canis familiaris SVEP1 VGNC VGNC:47006
Felis catus SVEP1 VGNC VGNC:65863
Mus musculus SVEP1 MGD MGI:1928849
Bos taurus SVEP1 VGNC VGNC:56985
Others SVEP1 NCBI